Formulation, Optimization and Evaluation of Flurbiprofen Liposomal Gel

Authors

  • Arun Raj. R Department of Pharmaceutical Sciences, RIMSR, Centre for Professional and Advanced Studies, Rubber board P O Kottayam 686009
  • Nikita Sara Abraham Department of Pharmaceutical Sciences, Mahatma Gandhi University RIMSR, Kottayam, Kerala, India

DOI:

https://doi.org/10.37591/(rrjops).v8i2.478

Abstract

 

The present study deals with effect of various combinations of lecithin, cholesterol, chloroform-methanol and tween-80 on liposomes of flurbiprofen. Optimization of the flurbiprofen liposomes by Design Expert software was done. Vesicle size, drug content, SEM and entrapment efficiency were evaluated. Flurbiprofen gel with optimized liposome using Carbopol 934 as gelling agents, were formulated. pH, spreadability and drug content in the gel were evaluated. Results of skin irritation study showed that formulation is nonirritant. Ex-vivo release study of flurbiprofen liposomal gel and gel with pure drug were compared using rat abdominal skin. This revealed that liposomal gel have better skin penetration than conventional gel. The kinetics of drug release followed Higuchi release with anomalous non-Fickian diffusion. The formulation was found to be stable even after accelerated stability study as per ICH guidelines.

 

Keywords: Flurbiprofen, liposomal gel, Box-Behnken design, optimization, ex-vivo release study

Cite this Article
Arun Raj R, Nikita Sara Abraham. Formulation, Optimization and Evaluation of Flurbiprofen Liposomal Gel. Research & Reviews: A Journal of Pharmaceutical Science. 2017; 8(2): 33–42p.

Downloads

Published

2019-06-17

Issue

Vol. 8 No. 2 (2017)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.