Novel Synthesis of Encapsulated Super Paramagnetic Iron Nanoparticles (Fe3O4) and its Evaluation in Drug Delivery System

Abstract

Nanoparticles can be defined as solid, submicron, colloidal particles ranging in size from 10–100 nm in diameter, generally but not necessarily made of natural or synthetic polymers, in which drugs can be adsorbed, entrapped, that exhibit new or enhanced size-dependent properties as compared to microparticles. Iron oxide nanoparticles are often magnetic by nature, which means that they obey Coulomb’s law, and can be manipulated by an external magnetic field gradient.Magnetic drug delivery system works on the delivery of magnetic nanoparticles (MNPs) loaded with drug to the tumor site under the influence of external magnetic field. MNPs because of their high magnetic responsiveness, biodegradability, high delivery efficiency and potential targeting function is a possible material as drug delivery system, since  drug-loaded MNPs can be directly injected into solid tumors and are expected to be held in place by an external magnetic field and release of  drug in controlled manner. In the present research study, synthesis, characterization and in vitro rate studies of super paramagnetic iron nanoparticles coated with oleic acid (OA) has been carried out. The nanoparticles synthesized in the present study had an average particle size of ~30 nm. Poly(lactic-co-glycolic acid)  (PLGA)-based polymeric nanocarrier encapsulated with the drug, i.e., β-Caryophyllene and MNPs as anticancer drug delivery was constructed. This efficiently reduces tumor growth thus providing a concept for the utilization of present formulation in sesquiterpene-based anticancer therapies. Evaluation of β-Caryophyllene loaded MNPs was successfully carried out and correlation coefficient (R²) value and drug released was found to be 0.999 and 97%, respectively for 48 h at pH 7.0. The entrapment efficiency and drug loading of β-Caryophyllene-MNPs in the PLGA-based nanoparticles was found to be high.

Keywords: Iron oxide nanoparticles, anticancer, β-Caryophyllene, less toxic chemicals

Cite this Article

Swathi D,Devi S, Nikitha. Novel Synthesis of Encapsulated Super Paramagnetic Iron Nanoparticles (Fe₃O₄) and its Evaluation in Drug Delivery System. Research and Reviews: A Journal of Pharmaceutical Science. 2016; 7(2): 11–24p.