Formulation and Evaluation of Verapamil Solid Dispersion Tablets for Solubility Enhancement

Abstract

This study was mainly designed to solve the drawbacks of conventional verapamil solid dosage form, low bioavailability and limited clinical efficacy, by preparing solid dispersion. Verapamil solid dispersion was developed by kneading method, melt solvent method and co-precipitation method to modify the release and enhance solubility of the drug. The physical state of the dispersed verapamil in the polymer matrix was characterized by differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy, Fourier-transform infrared spectroscopy, super saturation solubility testing and dissolution studies. Verapamil solid dispersions (FT 9) were formulated into tablets by direct compression method. On comparing with pure drug and physical mixture, the dissolution of verapamil solid dispersion was enhanced dramatically. Formulation FT 9 showed faster drug release in comparison to other formulations and marketed tablet. Formulation FT 9 follows first order kinetics and the release mechanism is super case II transport mechanism. The results of accelerated stability study indicated that there was no significant change in the tablets. The present study conclusively indicated that the use of various solid dispersion methods by using water soluble carriers improved the solubility of poorly water soluble drug.

Keywords: Solid dispersion, Verapamil, tablets, solubility enhancement

Cite this Article

Arun Raj R, Das Anju C, Sreerekha S, et al. Formulation and Evaluation of Verapamil Solid Dispersion Tablets for Solubility Enhancement. Research and Reviews: A Journal of Pharmaceutical Science. 2016; 7(1): 39–54p.