Open Access Open Access  Restricted Access Subscription or Fee Access

A Review Study on Phytochemical and Pharmacological Aspects of Berberis asiatica Roxb. ex DC.

Preeti Dobhal, Saumya Agnihotri, Sayyed Ashfaqullah, Sushma Tamta


Berberis asiatica, belongs to family Berberidaceae, is commonly known as Asian barberry or Kilmora. The plant is widely distributed in Himalayas. Research evidences support its use in various traditional medicinal formulas. Properties like antimicrobial, antidiebetic, anticancerous etc. have been reported in this plant. This review aims to highlight a comprehensive account of phytochemical constituents and pharmacological activities along with traditional uses in a view of many recent findings and its potential for future research.


Keywords: Anti-diebetic, Berberine, Himalayas, Kilmora, secondary metabolites


Cite this Article

Preeti Dobhal, Saumya Agnihotri, Sayyed Ashfaqullah, Sushma Tamta. A Review Study on Phytochemical and Pharmacological Aspects of Berberis asiatica Roxb. ex DC. Research & Reviews: A Journal of Pharmaceutical Science. 2020; 11(2): 8–15p.


Berberine, Himalayas, anti-diebetic, secondary metabolites

Full Text:




Watt G. A dictionary of the economic products of India. Published under the authority of Hos Majesty’”s Secretary of State for India in Council, Kolkata. London: Yohn Murry 1889.

Kirtikar KR and Basu BD Indian medicinal plants. Lalit Mohan Basu and Co., Allahabad,1933,pp105.

Nadkarni M. Indian materia medica,1954 Popular Book Depot, Mumbai.

Chatterjee R. The Rasanjana of Hindus Lloydia 1949 12: 178-182.

Rajasekaran A and Kumar N 2009. Rasont- A traditional crude drug prepared from Berberis sp. and its uses. Indian J Tradit Know.2009; 8(4): 562-563.

Rao RR, T Husain, B Datt et al. Revision of the Family Berberidaceae of India-I. Rheedea. 1998a; 8(1): 1-66.

Rao RR, T Husain, B Datt et al. Revision of the Family Berberidaceae of India-II. Rheedea. 1998b; 8(2): 109-143.

Patni S, Sah AN, Meena H, et al. A Physico-chemical, phyto-chemical and elemental analysis of stem bark and roots of Berberis asiatica Adv. Appl. Sci. Res. 2012; 3(6):3624-3628.

Dhar ML, Dhar MM, Dhawan BN et al. Screening of Indian medicinal plants for biological activity. Indian J. Exp. Biol., 1968; 6:232-247.

Rashmi, Rajasekaran A, Pant J. The Genus Berberis Linn.: A Review . Phcog Rev. 2008; 2,(4) :359-368.

Srivastava SK, Rawat AK and Mehrotra S. Pharmacognostic Evaluation of the Root of Berberis asiatica. Pharma. Biol. 2004; 42(6): 467-473.

Tiwari UL. Systematics And Ecology Of Berberidaceae In Uttarakhand State Thesis Submitted To The Forest Research Institute University Dehra Dun, Uttarakhand.2011

Rathi B, Sahu J, Koul S et al. Salient features of Berberis aristata and Berberis asiatica: A comparative pharmacognostical study. Der Pharmacia Lett. 2013; 5(2): 40-42.

Andola HC, Kailash SG, Rawal RS, et al. Influence of Environmental Factors on Production of Berberine Content in Berberis asiatica Roxb. ex DC in Kumaun West Himalaya. Indian J Herbs and Medicinal Plants. 2011; 17(4):329-338.

Dehar N, Walia R and Ratol S. Potentiation of thiopentone sodium induced hypnosis by Berberis aristata in rodents. Asian J Pharm Clin Res. 2012; 5(1):131–133

Bhakuni DS, Shoeb A, Popli SP. Chemical constituents of Berberis asiatica. Indian J Chem. 1968;6:123.

Rastogi RP, Mehrotra BM. Compendium of Indian Medicinal Plants. 3, New Delhi CDRI Lucknow and PID, 1993 694–696.

Belwal T, Dhyani P, Bhatt ID et al. Optimization extraction conditions for improving phenolic content and antioxidant activity in Berberis asiatica fruits using response surface methodology (RSM), Food Chemistry 2017

Bhatt ID, Rawat S, Badhani A et al. Nutraceutical potential of selected wild edible fruits of the Indian Himalayan region, Food Chemistry 2017.

Maithani A, Parchal V, Kumar D. Quantitative Estimation of Berberine content of Berberis asiatica from different altitude of garhwal Himalaya. Asian J Pharm Clin Res.2014; 7(1):165-167.

Patni S, Kumar N, Sah AN et al. Comparative hepatoprotective and antioxidant activity of Berberis asiatica stem bark and root. Egypt Pharmaceul J. 2017;16:184–191.

Shreshta PM, Dhillon SS Medicinal plant diversity and use in the highlands of Dolakha district. Nepal. J. Ethnophramacol. 2003; 86 (1): 81-96.

Sushrat Samhita. 1963 Sutrasthanam Lakshadi Group, Ed Bhishagratna KK, Chaukhamba Sanskrit Sansthan, Varanasi. India, 1:354.

Watt G (1883): Economic Products of India V. India, The Superintendent of Government Printing, New Delhi.

Anonymous 1988 The wealth of India Berberis, Linn (Berberidaceae), Ed Ambastha. Sp Pubication and Information Directorate, CSIR , New Delhi, India 2B: 114-118, .

Umera AK , Manoharan N, Sirajudeen J et al. Effect of some Indian traditional plants on few common pathogens Adv. Appl. Sci. Res. 2010; 1(3): 205-211.

Mahato JRB and Chaudhary RP Ethnomedicinal plants of Palpa district, Nepal. Scientific World. 2005; 3 (3): 26-31.

Singh A, Duggal S, Kaur N et al. Berberin: alkaloid with wide spectrum of pharmacological activites. J. Nat Prod.2010; 3:64-75.

Hashmi K , Hafiz A. In vivo antibacterial activity of Berberis asiatica. J Pakistan Med Assoc 1986; 36: 5–7.

Bhandari DK, Nath G, Ray AB et al.Antimicrobial Activity Of Crude Extracts From Berberis Asiatica Stem Bark Pharma. Biol. 2000; 38(4): 254-257.

Shah MG, Khan MA. Common medicinal folk recipes of Siran valley, Mansehra, Pakistan. Ethnobotanical Leaflets. 2006 ; 10:49-62.

Khosrokhavar R, Ahmadiani A, Shamsa F. Antihistaminic and anticholinergic activity of Methanolic Extract of Barberry Fruit (Berberis vulgaris) in the Guinea- Pig Ileum. J. Med. Plants, 2010; 9: 99-105.

Eidi A, Ghalam Z. Hepatoprotective effect of Berberis vulgaris L. extract on CCl4-induced toxicity in rats. Trauma Monthly.2011; 16:169–73.

Andola HC, Rawal RS, Bhatt ID. Antioxidants in fruits and roots of Berberis asiatica Rox, Ex.DC: A highly valued Himalayan plant. Natl. Acad. Sci. Lett. 2008; 31(11-12):337-340.

Norshazila S, Syed ZI, Suleiman MK. et al. Antioxidant Study of Selected Seeds of Malaysian Tropical Fruits. Malays. J. Nutr. 2010; 16(1): 149-159.

Shah NC , Joshi MC. An ethnobotanical study of the Kumaon region of India. Econ Bot. 1971; 25: 414–422.

Chauhan NS, Uniyal MR, Sannad BN : A preliminary study of the indigenous drugs used at the Tibetan Medicinal Centre, Dharmshala (H.P.). Nagarjun 1978-79; 22: 190–193.

Uniyal S K, Singh KN, Jamwal P. et al. Traditional use of medicinal plants among the tribal communities of Chhota Bhangal, Western HimalayaJournal of Ethnobiology and Ethnomedicine 2006; 2:14

Ghildiyal JC, Juyal P and Sadan G. Indigenous uses of plants in different women ailments in Garhwal region. Indian J. Pharm. Biol. Res. 2014; 2(1):39-44.

Doreswamy R, Sharma D, Plant Drug for liver disorder management. Indian Drugs. 1995; 32(4): 139-154.

Singh M, Srivastava S, Rawat AKS . Antimicrobial activites of Indian Berberis species Fitotrap. 2007; 78:574-576.

Chandra S, Sarla S and Alok K S Berberis asiatica Future Based Excellent Fruit In Nutritional Profile, Antimicrobial And Antioxidant Ingredients IRJP . 2011; 2 (12):213-216.

Gaur P, Bhatia S, Andola HC et al. In vitro radical scavenging and antimicrobial potential of Berebris asiatica Roxb. ec DC. Fruits extracts in four different processed forms. Indian J Trad. Know. 2017; 16 (4):706-713.

Kumar EP, Elshurafa AA, Elango K et al. Anti-tumour effect of Berberis asiatica roxb. Ex. Dc. On Dalton’s lymphoma ascite. Anc Sci Life.1998; 17:290-299.

Khan MMH, Rastogi C, Gupta S, et al. Protective effect of Berberis asiatica root on biochemical and histopathological changes in streptozotocin-induced diabetic Wistar rats Int J Basic Clin Pharmacol .2017; 6 (8) : 1880.

Kala CP. Indigenous knowledge of Bhotiya tribal community on wool dyeing and its present status in the Garhwal Himalaya. India. Curr Sci. 2002; 83(7):814–817.


  • There are currently no refbacks.

Copyright (c) 2020 Research and Reviews: A Journal of Pharmaceutical Science