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A Comprehensive Review on Chitosan Anticancer Property

S. Dhivya, S. Sarojini, S. Duraivel

Abstract


Chitosan, a hydrophilic, natural amino polysaccharide derived from chitin on alkaline de-acetylation. Chitosan is a nontoxic, biocompatible, antibacterial and biodegradable polymer. The biological activities of chitosan are mainly depending on the water solubility nature and also the solubility in other solvents. The primary amino group present in the chitosan is the key functional groups which is mainly responsible for its bioactivities. The biological activities of antimicrobial, antioxidant and anticancer properties depends on its de-acetylation capacity and the molecular weight of the chitosan.

 

Keywords: Anticancer property, biocompatible, biodegradable, chitin, chitosan

 

Cite this Article

S. Dhivya, S. Sarojini, S. Duraivel. A Comprehensive Review on Chitosan Anticancer Property. Research & Reviews: A Journal of Pharmaceutical Science. 2020; 11(2): 1–7p.


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References


Ramya R, Sudha PN, and Mahalakshmi J, “Preparation and Characterization of Chitosan Binary Blend,” International Journal of Scientific and Research Publications, 2, 1–9, 2012.

Yuan Y, Chesnutt BM, Haggard WO, and Bumgardner JD,“Deacetylation of chitosan: Material characterization and in-vitro evaluation via albumin adsorption and pre-osteoblastic cell cultures,” Materials, 4(8), 1399–1416, 2011.

Zhang ZT, Chen DH, and Chen L, “Preparation of two different serials of chitosan,” Journal of Dong Hua University (English Edition), 19, 36–39, 2002.

Gavhane YN, Gurav AS, and Yadav AV, “Chitosan and Its Applications: A Review of Literature,” International journal of research in pharmaceutical and biomedical sciences, 4(1), 312–331, 2013.

Park JH, Saravanakumar G, Kim K, and Kwon IC,“Targeted delivery of low molecular drugs using chitosan and its derivatives,” Advanced Drug Delivery Reviews, 62(1), 28–41, 2010.

Park K, Chung MJ, Choi HM, and Park YI, “Effects of the molecular weight and the degree of deacetylation of chitosan oligosaccharides on antitumor activity,” International Journal of Molecular Sciences, 12(1), 266–277, 2011.

Gunbeyaz M, Faraji A, Ozkul A, Purali N, and Senel S,“Chitosan based delivery systems for mucosal immunization against bovine herpes virus 1 (BHV-1),” European Journal ofPharmaceutical Sciences, 41(3), 531–545, 2010.

Wimardhani YS, Suniarti DF, Freisleben HJ, Wanadi SI, and Ikeda MA, “Cytotoxic effects of chitosan against oralcancer cell lines is molecular-weight-dependent and cell-typespecific,”International Journal of Oral Research, 3, 1, 2012.

Wimardhani YS, Suniarti DF, Freisleben HJ, Wanandi SI, Siregar NC, and Ikeda MA, “Chitosan exerts anticancer activity through induction of apoptosis and cell cycle arrest in oral cancer cells,” Journal of oral science, 56(2), 119–126, 2014.

Muzzarelli RAA, ed. Natural Chelating Polymers. New York: Pergamon Press, 83–227, 1973.

Zikakis JP, ed. Chitin, Chitosan and Related Enzymes. New York: Academic Press, 1974.

Kumar MNVR. A review of chitin and chitosan applications. React Funct Polym 2000; 46: 1–27.

Singla AK, Chawla M. Chitosan: some pharmaceutical and biological aspects – an update. J Pharm Pharmacol 2001; 53:1047–1067.

Dodane V, Vilivalam VD. Pharmaceutical applications of chitosan. Pharmaceutical science & technology today, 1: 246–253, 1998.

Gocho H, Shimizu H, Tanioka A, et al. Effect of polymer chain endon sorption isotherm of water by chitosan. CarbohydrPolym, 41: 87–90, 2000.

Skaugrud O. Chitosan – new biopolymer for cosmetics and drugs. Drug Cosmet Ind; 148: 24–29, 1991.

17 Nakatsuka S, Andrady LA. Permeability of vitamin-B-12 in chitosan membranes: effect of cross linking and blending with poly(vinyl alcohol) on permeability. J Appl Polym Sci; 44: 7–28, 1992.

Kubota N, Ohga K, Moriguchi M. Permeability properties of glycol chitosan membrane modified with thiol groups. J Appl Polym Sci; 42: 495–501, 1991.

Li Q, Dunn ET, Grandmaison EW, Goosen MFA. Application and properties of chitosan. J Bioact Compat Polym; 7: 370–397, 1992.

Miyazaki S, Yamaguchi H, Yokouchi C, et al. Sustained release and intra gastric floating granules of indomethacin using chitosan in rabbits. Chem Pharm Bull; 36: 4033–4038, 1988.

Sawayangi Y, Nambu N, Nagai T. Use of chitosan for sustained-release preparations of water soluble drugs. Chem Pharm Bull, 30: 4213–4215, 1982.

He P, Davis SS, Illum L. In vitro evaluation of the mucoadhesive properties of chitosan microspheres. Int J Pharm; 166: 75–88, 1998

He P, Davis SS, Illum L. Sustained release chitosan microsphere produced by novel spray drying methods. J Microencapsul; 16: 343–355, 1999.

Sawayangi Y, Nambu N, Nagai T. Enhancement of dissolution properties of griseofulvin from ground mixtures with chitin or chitosan. Chem Pharm Bull; 30: 4464–4467, 1982.

Shirashi S, Arahira M, Imai T, Otagiri M. Enhancement of dissolution rates of several drugs by low molecular weight chitosan and alginate. Chem Pharm Bull; 38: 185–187, 1990.

Leussen HL, Lehr CM, Rentel CO, et al. Bioadhesive polymers for the peroral delivery of drugs. J Control Release; 29: 329–338, 1994.

Leussen HL, Rentel CO, Kotze AF, et al. Mucoadhesive polymers in peroral peptide drug delivery, IV: polycarbophil and chitosan arepotent enhancers of peptide transport across intestinal mucosae invitro. J Control Release; 45: 15–23, 1997.

Tozaki H, Fujita T, Odoriba T, et al. Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on2,4,6-trinitrobenzene sulphonic acid-induced ulcerative colitis inrats. J Pharm Pharmacol; 51: 1107–1112, 1999.

Tozaki H, Fujita T, Odoriba T, et al. Colon specific delivery of R68070, a new thromboxane synthase inhibitor using chitosan capsules: therapeutic effects against 2,4,6-trinitrobenzene sulphonic acid-induced ulcerative colitis in rats. Life Sci; 64: 1155–1162, 1999.

Leong KW, Mao HQ, Truong-Le VL, et al. DNA-polycation nanospheres as non-viral gene delivery vehicles. J Control Release, 53: 183–193, 1998.

Kristl J, Smid-Korbar J, Struc E, et al. Hydrocolloids and gels of chitosan as drug carriers. Int J Pharm; 99: 13–19, 1993.

Tasker RA, Ross SJ, Dohoo SE, Elson CM. Pharmacokinetics of an injectable sustained-release formulation of morphine for use in dogs. J Vet Pharmacol Ther; 20: 362–367, 1997.

Remunan-Lopez C, Portero A, Vila-Jato JL, Alonso MJ. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. J Control Release; 55: 143–152, 1998.

Senel S, Ikinci G, Kas S, et al. Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery. Int J Pharm; 193: 197–203, 2000.

Kofuji K, Shibata K, Murata Y, et al. Preparation and drug retention of biodegradable chitosan gel beads. Chem Pharm Bull; 47: 1494–1496, 1999.

Sezer AD, Akbuga J. Release characteristics of chitosan-treated alginate beads, 1: sustained release of a macromolecular drug from chitosan treated alginate beads. J Microencapsul; 193: 197–203, 1999.

Ganza-Gonzalez A, Anguiano-Igea S, Otero-Espinar FJ, MendezJB. Chitosan and chondroitin microspheres for oral administration controlled release of metoclopromide. Eur J Pharm Biopharm; 48: 149–155, 1999.

Huang RG, Schwartz JB, Offner CM. Microencapsulation of chlorpheniramine maleate-resin particles with crosslinked chitosan for sustained release. Pharm Dev Technol; 4: 107–115, 1999.

Yomota C, Miyazaki T, Okada S. Sustained-release effect of thedirect compressed tablet based on chitosan and Na alginate. YakugakuZasshi; 114: 257–263, 1994.

Sabnis S, Rege P, Block LH. Use of chitosan in compressed tablets of diclofenac sodium: inhibition of drug release in an acidic environment. Pharm Dev Technol; 2: 243–255, 1997.

Takeuchi H, Yamamoto H, Niwa T, et al. Enteral absorption ofinsulin in rats from mucoadhesive chitosan-coated liposomes.Pharm Res; 13: 896–901, 1996.

Upadhyaya L, Singh J, Agarwal V, Pandey AC, Verma SP, et al. (2015) Efficient water soluble nanostructured ZnO grafted O-carboxymethyl chitosan/curcumin-nanocomposite for cancer therapy. Process Biochem 50: 678-688.

Wang G, Chen Y, Wang P, Wang Y, Hong H, Preferential tumor accumulation and desirable interstitial penetration of poly (lactic-co-glycolic acid) nanoparticles with dual coating of chitosan oligosaccharide and polyethylene glycol-poly (d, l-lactic acid). Acta Biomater 29: 248-260, 2016.

Maeda Y, Kimura Y, Antitumor effects of various low-molecular-weight chitosans are due to increased natural killer activity of intestinal intraepithelial lymphocytes in sarcoma 180–bearing mice. J Nutr 134: 945-950, 2004.

Park JK, Chung MJ, Choi HN, Park YI, Effects of the molecular weight and the degree of deacetylation of chitosan oligosaccharides on antitumor activity. Int J Mol Sci 12: 266-277, 2011.

El-Far M, Elshal M, Refaat M, El-Sherbiny IM, Antitumor activity and antioxidant role of a novel water-soluble carboxymethyl chitosan-based copolymer. Drug Dev Ind Pharm 37: 1481-1490, 2011.

Andreadis C, Vahtsevanos K, Sidiras T, Thomaidis I, Antoniadis K, and Mouratidou D, “5-Fluorouracil and cisplatin in the treatment of advanced oral cancer,” Oral Oncology, 39( 4), 380–385, 2003.

Remesh A, “Toxicities of anticancer drugs and its management,” International Journal of Basic & Clinical Pharmacology, 1(1), 2–12, 2012.

Gavhane YN, Gurav AS, and Yadav AV, “Chitosan and Its Applications: A Review of Literature,” International journal of research in pharmaceutical and biomedical sciences, 4(1), 312–331, 2013.

Bisht S and Maitra A, “Dextran-doxorubicin/chitosan nanoparticles for solid tumor therapy,” Wiley InterdisciplinaryReviews: Nanomedicine and Nanobiotechnology, 1(4), 415–425, 2009.

Medical University of South Carolina, “Study of Chitosan forPharmacologic Manipulation of AGE (Advanced Glycation End products) Levels in Prostate Cancer Patients,” Clinical-Trials.gov identifier: NCT03712371, 2018.

Basel University Hospital, “Comparison of Oral MorphineVersus Nasal Ketamine Spray with Chitosan in Cancer PainOutpatients,” ClinicalTrials.gov Identifier: NCT02591017, 2018.

Won Kim S and Samsung Medical Center, “Anti-adhesive Effect and Safety of a Mixed Solid of Poloxamer, Gelatinand Chitosan (Medichlore_) After Axillary Dissection forBreast Cancer,” ClinicalTrials.gov Identifier: NCT02967146,2018.

Segura Duran I, “University of Guadalajara, Chitosan Scaffoldfor Sellar Floor Repair in Endoscopic Endonasal TranssphenoidalSurgery,” ClinicalTrials.gov identifier: NCT03280849, 2018.

Zhang H, Wu F, Li Y, “Chitosan-based nanoparticlesfor improved anticancer efficacy and bioavailability of mifepristone,”Beilstein Journal of Nanotechnology, vol. 7, pp. 1861–1870, 2016.


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