Drugs and Polymers Used for Colon Specific Drug Delivery System with Current Trends: A Systematic Review

Authors

  • Atul N. Bendale Department of Pharmacy, TVES’s H. L. M. C. College of Pharmacy, Faizpur-425503, Tal. Yawal, Dist. Jalgaon, Maharashtra, India
  • Vijay R. Patil Department of Pharmacy, TVES’s H. L. M. C. College of Pharmacy, Faizpur-425503, Tal. Yawal, Dist. Jalgaon, Maharashtra, India
  • Bharat W. Tekade Department of Pharmacy, TVES’s H. L. M. C. College of Pharmacy, Faizpur-425503, Tal. Yawal, Dist. Jalgaon, Maharashtra, India
  • Vinod M. Thakare Department of Pharmacy, TVES’s H. L. M. C. College of Pharmacy, Faizpur-425503, Tal. Yawal, Dist. Jalgaon, Maharashtra, India

DOI:

https://doi.org/10.37591/(rrjops).v4i3.929

Abstract

 

Due to greater flexibility in design of dosage form and high patient compatibility, oral route of administration is the most preferred route but the gastrointestinal tract has many types of other undefeatable barriers to drug delivery. ‎In oral colon-specific drug delivery system, colon has a large amount of lymphoma tissue which facilitates direct absorption into the blood, negligible brush border membrane activity, and much less pancreatic enzymatic activity as compared with the small intestine. Colon in recent days offers great advantages for drug its physiological condition enriched for prolonging drug release time. Therefore, we can deliver the drug for systemic as well as local action through the colon. Local delivery mainly includes topical treatment of inflammatory bowel disease. This treatment can be made effective by targeting the drugs directly into the colon and we can reduce the systemic side effects. This review mainly includes drugs and polymers used so far in colonic drug delivery system and the primary approaches for CDDS (Colon Specific Drug Delivery) such as formation of prodrug, coating with pH dependent polymers, timed released system, designing formulation using polysaccharides, hydrogels, bioadhesive system, pressure-dependent drug delivery, CODESTM, osmotic drug delivery system which are unique in terms of achieving in vivo site specificity, and feasibility of manufacturing process.

 

Keywords: Colon drug delivery system, prodrug, pH, microbially triggered, CODES

Downloads

Published

2021-01-13

Issue

Vol. 4 No. 3 (2013)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.