Rapid Determination of Content of Etoricoxib in Pharmaceutical Formulations by Mid-Infrared Spectroscopy

Authors

  • Jivasha . University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India

DOI:

https://doi.org/10.37591/(rrjops).v4i3.931

Abstract

 

The present paper is an attempt to highlight a new technique FTIR-ATR along with its referenced validated method, UV spectrophotometric analysis. Different concentrations of etoricoxib were used as samples to draw standard plot. From different samples, a transmission spectrum was recorded according to the prominence of peaks. The present study has chosen the three most prominent peaks for analytical purpose in case of samples of etoricoxib and marketed formulations. All the experimental data obtained was subjected to statistical analysis, using one-way analysis of variance (ANOVA) and multiple linear regression analysis to obtain quantitative information. ANOVA one-way was applied to FTIR-ATR data of pure drug etoricoxib to build calibration of data (standard plot), which enabled prediction of etoricoxib amount in pharmaceutical formulations A and B, p < 0.001. The results obtained by FTIR-ATR method were validated by using reference UV spectrophotometric method by t-test paired (α = 0.5%) and Scheffe test (homogenous subsets). The finding of the study inferred that FTIR-ATR provides a high-performance approach for etoricoxib quantitative determination in order to check the label-claimed content in different pharmaceutical formulations within the stipulated analytical limits of 90 mg ± 10%. From the above analysis, we can say that the amount of drug present in different formulations obtained from FTIR-ATR method is same as that of UV-spectrophotometric analysis (validation method). Also, the concentration transmittance value (log IO/IT) changes linearly and follows Lambert-Beer law. The analytical procedure is simple, rapid, non-destructive and easy to use as it requires no sample pretreatment and reagent-free measurement. Great precision is needed because of quality control in pharmaceutical industry as it constitutes a powerful alternative to separative method for quality control analysis of pharmaceuticals. Further, it adds an advantage in analyzing formulations containing rapid-absorption drug.

 

Keywords: UV spectrophotometric analysis, transmission spectrum, linearity of data, quality control analysis, formulations, quantitative determination

Downloads

Published

2021-01-13

Issue

Vol. 4 No. 3 (2013)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.