Synthesis, Crosslinking and Evaluation of Graft Polymer for Biomedical Use

Abstract

The objective of this research was focused on grafting of acrylic acid (AA) with hydroxypropyl methylcellulose (HPMC) to obtain copolymers of hydrogels with improved properties for ease of administration and reducing the dose frequency, improved patient compliance and comfort of sustained release medication. Water-absorbing polymers for hydrogels, the swellable polymeric materials have been widely investigated as the carrier for drug delivery system. These are the advanced polymer systems that hold special advantages for delivery of biological drugs and enhancing the biocompatibility of implantable devices. Here polysaccharides fabricated into hydrophilic matrices remain popular biomaterials for controlled release dosage forms. Hydrogel was prepared by in situ emulsifier-free emulsion polymerization using benzyl peroxide as an initiator through primary stage grafting. Acrylic acid could intercalate into layers of HPMC forms graft polymer composite. FTIR spectroscopy helps in determining the backbone functional groups. From Dynamic thermal gravimetric analysis (TGA) temperature is measured using differential scanning calorimetry (DSC).

Keywords: Graft polymer, acrylic acid, HPMC, FTIR, DSC