Open Access Open Access  Restricted Access Subscription or Fee Access

Role of Alkalinized Topical Heparin and Lignocaine Preparation in Burn Wound

Ravi Kumar Chittoria, Dr Killi Madhu Babu, Barath Kumar Singh. P

Abstract


Burns can severely damage a patient's physical and mental health. We should consider pain, hospital stays, lost workdays, and financial strain while handling these patients. Burn patients need rapid specialist care to reduce morbidity and death. Heparin is anti-inflammatory, allergic, histaminic, serotonin-blocking, and proteolytic enzyme-blocking. Topical forms have been used to prevent burn extension, limit skin tissue loss, promote quicker healing with fewer contractures, relieve pain, reduce tissue oedema and weeping, prevent infection, and promote revascularization, granulation, and epithelialization of deeply burned tissue. Topical lignocaine application in gel formulation has been tried in raw areas and post skin grafting raw areas. Positive results have been obtained demonstrating significant pain relief with use of topical local anesthetic. In addition to pain, it is shown to reduce edema and post burn ischemia. We here discuss mixture of topical heparin and local anesthetic in burn care in this case report.

Keywords


Topical heparin, lignocaine, alkalinized, burn, wound, management.

Full Text:

PDF

References


Teot L, Otman S, Brancati A, Mittermayr R. Burn scar treatment. In: Kamolz LP, Jescheke MG, Horch RE, Küntscher M, Brychta P, editors. Handbook of Burns. Vienna: Springer; 2012. p. 55 67.

Masoud M, Wani AH, Darzi MA. Topical heparin versus conventional treatment in acute burns: a comparative study. Indian J Burns 2014;22: 43 50.

Catherine J. Sinnott, B.A.Joseph M. Garfield, M.D.Johannes G. Thalhammer, D.V.M.; Gary R. Strichartz, Ph.D. Addition of Sodium Bicarbonate to Lidocaine Decreases the Duration of Peripheral Nerve Block in the Rat. Anesthesiology October 2000, Vol. 93, 1045–1052.

C. Lowell Parsons; Paul Zupkas; Jeffrey Proctor; James Koziol; Amie Franklin; Dennis Giesing; Edward Davis; Charles M. Lakin; Bruce S. Kahn; William J. Garner (2012). Alkalinized Lidocaine and Heparin Provide Immediate Relief of Pain and Urgency in Patients with Interstitial Cystitis., 9(1), 207–212.

Alrich EM. The effect of heparin on the circulating blood plasma and proteins in experimental burns. Surgery 1949;25: 676 80.

Lu J, Xu T, Yang M, Xu XW, Wu B. Heparin for the treatment of burns (Protocol). Cochrane Database Syst Rev 2011;12:CD009483.

Reyes A, Astiazaran JA, Chavez CC, Jaramillo F, Saliba MJ. Burns treated with and without heparin: controlled use in a thermal disaster. Ann Burns Fire Disasters 2001;14: 183 91.

Saliba MJ Jr, editor. The Effects of Heparin in the Treatment of Burns. Proceedings of International Meeting; 1994 Feb 24 27. 9.Vijayakumar C, Prabhu R, Senthil Velan M, et al. (August 17, 2018) Role of Heparin Irrigation in the Management of Superficial Burns with Special Reference to Pain Relief and Wound Healing: A Pilot Study. Cureus 10(8): e3157.

Saliba MJ Jr, Dempsey WC, Kruggel JL. Large burns in humans. Treatment with heparin. JAMA 1973;225: 261 9.

Ferreira Chacon JM, Mello de Andrea ML, Blanes L, Ferreira LM. Effects of topical application of 10,000 IU heparin on patients with perineal dermatitis and second degree burns treated in a public pediatric hospital. J Tissue Viability 2010;19: 150 8.

Elsayed E, Becker RC. The impact of heparin compounds on cellular inflammatory responses: a construct for future investigation and pharmaceutical development. J Thromb Thrombolysis 2003;15: 11 8.

Saliba M.J. Heparin in the treatment of burns: A review. Burns. 2001;27: 348-357.

Rayes A., Astiazaran J.A., Chavez C.C., Jaramilla F., Saliba M, J. Burns treated with and without heparin: Controlled use in a thermal disaster. Annals of Burns and Fire Diasters. 2001;14: 183-191. 15.Vigneault L, turgeon AF, Côté D, Lauzier F, Zarychanski R, Moore L, ct al.Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials. Can J Anesth Can Anesth. 2011 Jan 1;58(1):22-37.

Wasiak J, Spinks A, Costello V, Ferraro F, Paul E, Konstantatos A, et al. Adjuvant use of intravenous lidocaine for procedural burn pain reliet: A randomized double-blind, placebo-controlled, cross-over trial. Burns. 2011 Sep;37(6):951-7.

Wasiak J, Mahar PD, McGuinness SK, Spinks A, Danilla S, Cleland H, et al. Intravenous lidocaine for the treatment of background or procedural burn pain. Cochrane Database of Systematic Reviews.Chisester, UK: John Wiley & Sons, Ltd; 2014

B T Brofeldt 1, P Cornwell, D Doherty, K Batra, R A Gunther, Topical lidocaine in the treatment of partial-thickness burns, J Burn Care Rehabil.,1989 Jan-Feb;10(1):63-8.




DOI: https://doi.org/10.37591/tdd.v10i2.1336

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 Trends in Drug Delivery