Current Trends in Crossing the Blood–Brain Barrier: A Review
Abstract
Keywords
Full Text:
PDFReferences
Ehrlich P. Das sauerstufbudurfnis des organismus. In: Eine Farbenanalytische Studie. Berlin: Hirschwald; 1885.
Goldmann E. Vitalfärbung am zentralnervensystem. Abhandl Königl preuss Akad Wiss 1; 1913.
Reese TS, Karnovsky MJ. Fine structural localization of a blood–brain barrier to exogenous peroxidase. J Cell Biol 1967; 34:207–17 [4] Oldendorf WH, Cornford ME, Brown WJ. The large apparent work capability of the blood–brain barrier: a study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat. Ann Neurol1977;1:409–17,
Daneman R, Zhou L, Kebede AA, Barres BA. Pericytes are required for blood–brain barrier integrity during embryogenesis. Nature 2010;468:562–6,
Shepro D, Morel NM. Pericyte physiology. FASEB J 1993;7:1031–8 [7] Hamilton NB, Attwell D, Hall CN. Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease. Front Neuroenerg 2010;2.
PardridgeWM. The blood–brain barrier: bottleneck in brain drug development. NeuroRx 2005;2:3–14.
Laschinger M, Engelhardt B. Interaction of alpha4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro. J Neuroimmunol 2000; 102:32–43
Greenwood J, Amos CL, Walters CE, Couraud P-O, Lyck R, Engelhardt B, et al. Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration. J Immunol 2003; 171:2099–108. [11] Reese TS, Karnovsky MJ: Fine structural localization of a blood brain barrier to exogenous peroxidase. J Cell Biol 1967, 34:207-217. [12] Banks WA: Are the extracellular pathways a conduit for the delivery of therapeutics to the brain? Curr Pharm Des 2004, 10:1365-1370.
Broadwell RD: Transcytosis of macromolecules through the blood-brain barrier: a cell biological perspective and critical appraisal. Acta Neuropathol 1989, 79:117-128
Begley DJ: ABC transporters and the blood-brain barrier. Curr Pharm Des 2004, 10:1295-1312.
Davson H, Welch K, Segal MB: Some special aspects of the blood-brain barrier. In The Physiology and Pathophysiology of the Cerebrospinal Fluid Edinburgh: Churchill Livingstone; 1987:247-374 [16] Banks WA, Moinuddin A, Morley JE: Regional transport of TNF-α across the blood-brain barrier in young ICR and young and aged SAMP8 mice. Neurobiol Aging 2001, 22:671-676
Gao, X.P.; Kouklis, P.; Xu, N.; Minshall, R.D.; Sandoval, R.; Vogel, S.M.; Malik, A.B. Reversibility of increased microvessel permeability in response to VE-cadherin disassembly. Am. J. Physiol. Lung Cell. Mol. Physiol. 2000, 279, L1218–L1225.
Rosenberg, G.A. Blood-Brain Barrier Permeability in Aging and Alzheimer’s Disease. J. Prev. Alzheimers Dis. 2014, 1, 138–139.
Van Tellingen, O.; Yetkin-Arik, B.; de Gooijer, M.C.; Wesseling, P.; Wurdinger, T.; de Vries, H.E. Overcoming the blood-brain tumor barrier for effective glioblastoma treatment. Drug Resist. Updates 2015, 19, 1–12.
Kooij, G.; van Horssen, J.; Bandaru, V.V.; Haughey, N.J.; de Vries, H.E. The Role of ATP-Binding Cassette Transporters in Neuro-Inflammation: Relevance for Bioactive Lipids. Front. Pharmacol. 2012, 3, 74.
Thomas, C.; Tampe, R. Structural and Mechanistic Principles of ABC Transporters. Annu. Rev. Biochem. 2020, 89, 605–636.
Hotz, J.M.; Thomas, J.R.; Katz, E.N.; Robey, R.W.; Horibata, S.; Gottesman, M.M. ATP-binding cassette transporters at the zebrafish blood-brain barrier and the potential utility of the zebrafish as an in vivo model. Cancer Drug Resist. 2021, 4, 620–633.
Lai, J.I.; Tseng, Y.J.; Chen, M.H.; Huang, C.Y.F.; Chang, P.M.H. Clinical Perspective of FDA Approved Drugs with P-Glycoprotein Inhibition Activities for Potential Cancer Therapeutics. Front. Oncol. 2020, 10, 2336.
Kakkis, E.D.; Muenzer, J.; Tiller, G.E.; Waber, L.; Belmont, J.; Passage, M.; Izykowski, B.; Phillips, J.; Doroshow, R.; Walot, I.; et al. Enzyme-replacement therapy in mucopolysaccharidosis I. N. Engl. J. Med. 2001, 344, 182–188.
Muenzer, J.; Hendriksz, C.J.; Fan, Z.; Vijayaraghavan, S.; Perry, V.; Santra, S.; Solanki, G.A.; Mascelli, M.A.; Pan, L.Y.; Wang, N.; et al. A phase I/II study of intrathecal idursulfase-IT in children with severe mucopolysaccharidosis II. Genet. Med. 2016, 18, 73–81
[10:33 am, 14/09/2023PS: 71.Kakkis, E.D.; Muenzer, J.; Tiller, G.E.; Waber, L.; Belmont, J.; Passage, M.; Izykowski, B.; Phillips, J.; Doroshow, R.; Walot,I.;etal.Enzyme-replacement therapy in mucopolysaccharidosis I. N. Engl. J. Med. 2001, 344, 182–188
Egleton, R.D.; Davis, T.P. Development of neuropeptide drugs that cross the blood-brain barrier. NeuroRx J. Am. Soc. Exp. NeuroTher. 2005, 2, 44–53
Terstappen, G.C.; Meyer, A.H.; Bell, R.D.; Zhang, W.D. Strategies for delivering therapeutics across the blood-brain barrier. Nat.Rev. Drug Discov. 2021, 20, 362–383
Pulgar, V.M. Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges. Front. Neurosci. 2019, 12, 1019
Elliott, R.O.; He, M. Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery. Pharmaceutics 2021,13, 122.
Penfornis, P.; Vallabhaneni, K.C.; Whitt, J.; Pochampally, R. Extracellular vesicles as carriers of microRNA, proteins and lipids in tumor microenvironment. Int. J. Cancer 2016, 138.
Armstrong, J.P.K.; Holme, M.N.; Stevens, M.M. Re-Engineering Extracellular vesicles as Smart Nanoscale Therapeutics. Acs Nano2017, 11, 69–83
Hjouj, M.; Last, D.; Guez, D.; Daniels, D.; Sharabi, S.; Lavee, J.; Rubinsky, B.; Mardor, Y. MRI Study on Reversible and Irreversible Electroporation Induced Blood Brain Barrier Disruption. PLoS ONE 2012, 7, e42817
Vagner, T.; Dvorzhak, A.; Wojtowicz, A.M.; Harms, C.; Grantyn, R. Systemic application of AAV vectors targeting GFAP-expressing astrocytes in Z-Q175-KI Huntington’s disease mice. Mol. Cell. Neurosci. 2016, 77, 76–86
Serlin Y, Shelef I, Knyazer B, Friedman A. Anatomy and physiology of the blood-brain barrier. Semin Cell Dev Biol. 2015 Feb;38:2-6. doi: 10.1016/j.semcdb.
DOI: https://doi.org/10.37591/tdd.v10i2.1342
Refbacks
- There are currently no refbacks.
Copyright (c) 2023 Trends in Drug Delivery