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Anatomization On Controlled Drug Delivery System

Bhupendra Manohar Mahale, Bhagyashri S.Pimpale, Sandip.A. Tadavi, Sulbha.G Patil

Abstract


Modern target-perception technologies have led to the development of successful controlled drug delivery systems. The process of administering a medication so that it is clinically effective in either people or animals is known as drug supply. Several of the earliest controlled-release systems aimed to achieve a delivery profile that would result in a high drug level in the blood for an extended length of time. When using conventional medication delivery methods, the drug level in the blood follows a pattern where it increases with each dosage and then decreases until the subsequent administration. The advancement of DDS, which includes the utilization of multiple carrier membranes to control longer delivery times with little variation in delivery velocity, has in recent years, speed has received an overwhelming amount of attention. Over the past forty years, controlled release (CR) drug delivery systems have become more and more popular because of their numerous therapeutic benefits. Systems for controlled drug distribution have been created to accelerate the medication's subsequent bodily stages. This delivery system enhanced the patient obedience specifically with durable treatments for chronic diseases. Traditional dosing forms result in a change in the drug's concentration in plasma. The drug dynamics within the body, such as absorption, distribution, metabolism, and excretion, determine these fluxes. This kind of drug concentration flux in plasma is eliminated by controlled release. Controlled-release medications, regardless of delivery method, are typically designed to guarantee that the medication's rate of absorption and excretion are similar. This articles has been prepared as per the syllabus of PCI For the chapter in the subject Drug Delivery System of M.Pharmacy.

Keywords


Controlled release, Drug delivery enzyme activated system, Self-regulated drug delivery system, and Mechanically activated drug delivery system, Modified – release.

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References


Patil Prafull P, Gayakwad Bhushan P, Md. Rageeb, Md. Usman, Surajj Sarode. Book of Drug Delivery System. Pee Vee Publication. 2020; 83p.

Myer Kutz, editor. Standard Handbook of Biomedical Engineering and Design. In: Shen Steve I, Jasti Bhaskara R, Xiaoling Li (University of the Pacific, Stockton, California). Chapter 22 Design of Controlled-Release Drug Delivery Systems. GlobalSpec: The McGraw-Hill Companies, Inc.; 2003.

Chien YW, Lin S. Drug delivery: Controlled release. In: Encyclopedia of pharmaceutical technology. Vol. 1. Boca Raton; 2002; 811–833.

Kost J, Langer R. Responsive polymeric delivery systems. Adv Drug Deliv Rev. 2012; 64: 327–341.

Bhowmik D, Pusupoleti KR, Duraivel S, Kumar KS. Recent approaches in transdermal drug delivery system. Pharma Innov. 2013; 2(3): 99–108.

Chien Y. Novel drug delivery systems. 2nd Edn. Boca Raton: CRC Press: 1991.

Satav SS, Bhat S, Thayumanavan S. Feedback regulated drug delivery vehicles: Carbon dioxide responsive cationic hydrogels for antidote release. Biomacromolecules. 2010; 11(7): 1735–1740.

Bertrand N, Wu J, Xu X, Kamaly N, Farokhzad OC. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv Drug Deliv Rev. 2014; 66: 2–25.

Joshi G, Singh PK, Negi A, Rana A, Singh S, Kumar R. Growth factors mediated cell signalling in prostate cancer progression: implications in discovery of anti-prostate cancer agents. Chem Biol Interact. 2015; 240: 120–133.

Robert Langer. New methods of drug delivery. Science. Sep 1990; 249(4976): 1527–1533. DOI: 10.1126/science.2218494.

Zhang Y, Chan HF, Leong KW. Advanced materials and processing for drug delivery: the past and the future. Adv Drug Deliv Rev. 2013; 65(1): 104–120.

Hrubý M, Filippov SK, Štěpánek P. Smart polymers in drug delivery systems on crossroads: Which way deserves following? Eur Polym J. 2015; 65: 82–97.

Langer R. Invited review polymeric delivery systems for controlled drug release. Chem Eng Commun. 1980; 6(1–3): 1–48.




DOI: https://doi.org/10.37591/tdd.v10i3.1382

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