Preparation and Evaluation of Mucoadhesive Bilayered Buccal Patch using HPMC and Gelatin

Authors

  • Anjali Patel M.Pharma Student, Department of Pharmaceutics, School of pharmacy, Chouksey Engineering College, Bilaspur, Chhattisgarh, India
  • Basudha Singh Gautam Assistant Professor, Department of Pharmaceutics, School of Pharmacy, Chouksey Engineering College, Bilaspur, Chhattisgarh, India
  • Utpal Jana Head of Department, Department of Pharmaceutics, School of Pharmacy, Chouksey Engineering College, Bilaspur, Chhattisgarh, India

Keywords:

Bilayered patch, bioavailability, buccal drug delivery, mucoadhesion, plasticizer

Abstract

The buccal drug delivery system has gained more popularity than other drug delivery systems owing to its ease and safe administration. The high permeability of the buccal mucosa allows the drug to reach the systemic circulation and gives rapid onset of action. The buccal route also helps to avoid drug degradation from first-pass hepatic metabolism and improves drug bioavailability. The present study is designed to develop and evaluate the mucoadhesive buccal patches using HPMC (Hydroxypropyl Methyl Cellulose) and gelatine. The patches were prepared by the solvent casting method. Propylene glycol (PG) and Dimethyl sulfoxide (DMSO) was used as plasticizer and permeation enhancer, respectively. HPMC was used as a mucoadhesive polymer. The developed bilayered patch was evaluated for thickness, weight, moisture content, folding endurance, moisture uptake, etc. The drug content uniformity, drug permeability, and drug release study from the patches was investigated using ascorbic acid as a model drug. The results indicated that the bilayered buccal patch can be prepared successfully using HPMC as a mucoadhesive polymer with adequate mucoadhesion.

References

Shiledar RR et al. Formulation and in vitro evaluation of xanthan gum-based bilayered mucoadhesive buccal patches of zolmitriptan. Carbohydrate Polymers. 2014; 101: 1234–1242.

Abruzzo Angela, Barbara Luppi et al. Mucoadhesive chitosan/gelatin films for buccal delivery of propranolol hydrochloride. Carbohydrate Polymer. 2012; 87(1): 581–588.

Patel VM et al. Recent advances in buccal drug delivery. Current Pharma Research Journal. 2006; 1(2): 25–33.

Junginger HE, Hoogstraate JA, Coos Verhoef J. Recent advances in buccal drug delivery and absorption in vitro studies. Journal of Controlled Release. 1999; 62(1–2): 149–159.

Patel Mitul et al. The current interest on buccal drug delivery system. International Journal of Pharmacy. 2011; 2(12).

Chowdary K PR, et al. Mucoadhesive drug delivery system: a review of current status. Indian Drugs. 2000; 37(9): 400–406.

Senel S, et al. Delivery of bioactive peptides and proteins across oral (buccal) mucosa. Curr Pharma Biotechnol. 2001; 2(2): 175–186.

PB Koyi, AB Khan. Buccal patches: A review. International Journal of Pharmaceutical Sciences and Research. 2013; 4(1): 83–89.

Eastoe JE. The amino acid composition of mammalian collagen and gelatin. Biochem. J. 1955; 61(4): 589–600.

Kodjo Boady Djagny et al. Gelatin: a valuable protein for food and pharmaceutical industries. Reviews in Food Science and Nutrition. 2001; 41(6): 481–492.

Takahashi et al. Studies on the properties of fractionated gelatins. J Photogr Sci. 1996; 44(5): 136–146.

Chambial Shailja et al. An overview on vitamin C in disease prevention and cure. Indian Journal Clin Biochem. 2013; 28(4): 314–328.

Wilson JX. Regulation of vitamin C transport. Ann Rev Nutr. 2005: 25: 105–125.

Malo C, Wilson JX. Glucose modulates vitamin C transport in adult human small intestinal brush border membrane vesicles. J Nutr. 2000; 130(1): 63–69.

Anuj Kumar et al. Formulation development and evaluation of carvedilol bioerodable buccal mucoadhesive patch. Pharmacie Globale. Int J. Comprehensive Pharma. 2011; 3(7): 1–5.

Sahni J, Raj S, et al. Design and in vitro characterization of buccoadhesive drug delivery system of insulin. Indian Journal of Pharmaceutical Sciences. 2008; 70(1): 61–65.

Semalty et al. Muoadhesive buccal fim of glipizide. Indian Journal of Pharmaceutical Sciences. 2008; 70(1): 43–48.

MA Hussain et al. A comprehensive review on buccal drug delivery system. American Journal of Advance Drug Delivery. 2013; 3(11): 300–312.

Attama AA et al. Noval buccoadhesive delivery system of hydrochlorothiazide formulated with ethyl cellulose, hydroxy-propyl methylcellulose interpolymer complex. Scientific Res Essay. 2008; 3(8): 343–347.

Hibah M Aldawsari, Shaimaa M Badr-Eldin. Enhanced pharmacokinetic performance of dapoxetine hydrochloride via the formulation of instantly-dissolving buccal films with acidic pH modifier and hydrophilic cyclodextrin: factorial analysis, in vitro and in vivo assessment. Journals of Advance Research. 2020; 24: 281–290.

Koland M et al. Mucoadhesive films of losartan potassium for buccal delivery: Design and characterization. Indian Journal of Pharmaceutical Education and Research. 2010; 44(4): 315–323.

A Kaur, G Kaur. Mucoadhesive buccal patches based on interpolymer complexes of chitosan-pectin for delivery of carvedilol. Saudi Pharmaceutical Journal. 2012; 20(1): 21–27.

Ratha Adhikari, et al. Formulation and evaluation of buccal patches for delivery of atenolol. AAPS PharmSciTech. 2010; 11(3): 1038–1044.

Patel VM, Prajapati BG, Patel MM. Effect of hydrophilic polymers on buccoadhesive eudragit patches of propranolol hydrochloride using factorial design. AAPS PharmSciTech. 2007; 8(2): E119–E126.

Amelia M Avachat, Kishore N Gujar, Kishor V Wagh. Development and evaluation of tamarind seed xyloglucan-based mucoadhesive buccal films of rizatriptan benzoate. Carbohydrate Polymers. 2013; 91(2): 537–542.

Downloads

Published

2021-06-16

Issue

Vol. 8 No. 1 (2021)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.