Open Access Open Access  Restricted Access Subscription or Fee Access

In-Vitro Evaluation of Extended Release Atorvastatin Tablets by using Natural Gums

P. Venkatesh, S. K. Godasu, G. S.V. Divya Jyothi, V. Rajashakar

Abstract


The present research is the formulation of extended-release tablets Atorvastatin is used as a hypoglycemic agent; it is HMG CoA Reductase inhibitor. All the formulation were prepared with using different grades of xanthan gum, guar gum, sodium alginate, then all the formulations were subjected to pre-compression and post-compression parameters such as angle of repose, bulk density, tapped density, Carr’s index, Hausner's ratio, weight variation, thickness, hardness, friability and drug content. All the formulations were showed within IP specifications. Total weight of the tablets was considered as 200 mg. The “9” formulations were carried out in-vitro drug release studies. Among all the formulations “F6” formulation containing guar gum was showed a maximum percentage of drug release up to 12 hours. So, this is the optimized formula and applied release kinetics to optimized formula, and it followed zero-order release kinetics.

Keywords: Atorvastatin, extended-release tablets, natural gums

Cite this Article

P. Venkatesh, S. K. Godasu, G.S.V. Divya Jyothi, V. Rajashakar. In-Vitro Evaluation of Extended Release Atorvastatin Tablets by using Natural Gums. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2019; 6(2): 55–62p.


Full Text:

PDF

References


REFERENCES:

Sathish Ummadi, B. Shravani et al. Overview On Controlled Release Dosage Form. International Journal Of Pharma Sciences, 2013; 3(4): 258-269

Marleen Schonewille, Jan Freark De Boer et al. Statins Increase Hepatic Cholesterol Synthesis And Stimulate Fecal Cholesterol Elimination In Mice. Journal Of Lipid Reaserch, 2016; 57(8): 1455–1464

Handbook of Modern Pharmaceutical Analysis Edward Lau, In separation science and technology, 2001

Final text for addition to the international pharmacopoeia, World health organization , 2012

Birtok. A. Oral And Formulated Pharmaceutical preparations before The invention of Tablets. 2009; 55(14):171-82

Daljit Masih1, Rajesh Gupta, Formulation And Evaluation Of Mouth Dissolving Tablets Of Tolperisone, UK Journal Of Pharmaceutical And Biosciences, 2013; 1(1): 1-6

Alok Kumar Gupta, Anuj Mittal And Prof. K. K. Jha, Fast dissolving tablet- A Review. The pharma innovation, 2012; 1(1)

Yalla Karunakar Reddy, G. S.Valluri. Formulation and invitro evaluation of metronidazole tablets for colon targetted drug delivery system. Indo american journal of pharmaceutical sciences, 2016; 3 (12): 1534-1545.

Mohammad Saleem, Mohammad Shahin et al. Evaluation of tablets by friability apparatus. International journal of research in pharmacy and chemistry, 2014; 4(4): 837-840


Refbacks

  • There are currently no refbacks.


Copyright (c) Research & Reviews: A Journal of Drug Formulation, Development and Production