DESIGNING OF COUMARIN ANALOGS: A NEW INSIGHT AS ENOL ACYL CARRIER PROTEIN REDUCATSE INHIBITORS

Authors

  • MONIKA KAKADIYA Shree Dhanvatary Pharmacy college, kim
  • MOGAL AZMIN Department of Pharmaceutical Chemistry, Shree Dhanvantary Pharmacy College, Kim, Gujarat
  • MALLESHAPPA N. NOOLVI Department of Pharmaceutical Chemistry, Shree Dhanvantary Pharmacy College, Kim, Gujarat

Abstract

Tuberculosis was almost certainly the leading cause of death in Europe and the United States in recorded history, although because of the multifarious forms of the disease. Based on literature we have designed coumarin linked with thiadiazole derivatives as antitubercular agents. To determine structural requirements, we carried out molecular docking study in which we found that our designed molecule have similar binding with enoyl acyl carrier protein reductase (InhA). The docking studies results showed that the compound 6, 15 and 27 showed more binding energy with InhA mutant than that of reference compound Isoniazid.

 

Keywords: Tuberculosis, InhA, Coumarin, Molecular modeling

Cite this Article

Monika Kakadiya, Mogal Azmin, Malleshappa N. Noolvi. Designing of Coumarin Analogs: A New Insight as Enol Acyl Carrier Protein Reducatse Inhibitors, 2019. Research & Reviews: A Journal of Drug Design & Discovery. 2019; 6(2): 1–5p

Author Biography

  • MONIKA KAKADIYA, Shree Dhanvatary Pharmacy college, kim
    Department of pharmaceutical chemistry

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Published

2019-08-28

Issue

Vol. 6 No. 2 (2019)

Section

Research Article

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