Hepatoprotective Role of Exogenous Melatonin and Insulin Plant (Costus IgneousNak.) Extract against the Streptozotocin Induced Diabetes in Rats

Authors

  • Adyasha Purohit Department of ZoologyGuru Ghasidas Vishwavidyalaya, Bilaspur
  • Seema Rai Department of ZoologyGuru Ghasidas Vishwavidyalaya, Bilaspur
  • Younis Ahmad Hajam Department of ZoologyGuru Ghasidas Vishwavidyalaya, Bilaspur
  • Hindole Ghosh Department of ZoologyGuru Ghasidas Vishwavidyalaya, Bilaspur
  • Muddasir Basheer Department of ZoologyGuru Ghasidas Vishwavidyalaya, Bilaspur

Abstract

The aim of the present study was to compare hepatoprotective efficacy of exogenous melatonin and insulin plant extract against streptozotocin induced hepatic complications. To induce diabetes adult female rat were administrated with STZ (15mg/kg) for consecutive six days. The confirmation of diabetic model was analyzed by blood glucose test. Following confirmation diabetic rat model were treated with exogenous MEL intraperitoneally and plant extract was administered orally. Administration of MEL and plant extract to STZ induced diabetic rat showed a significant decrease of lipid peroxidation (TBARS) in liver tissue comparable to the control group of rats. In addition, plant extract and melatonin prevented the decrease in anti-oxidative enzyme parameters viz. superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) of hepatic tissues. Both the melatonin and plant extract showed significant recovery however, plant extract showed significantly higher protection to restore the hepatic alteration in comparison to melatonin administered group of female rats. The histological observations showed damages by STZ in hepatic lobules as the therapeutic potential of melatonin and plant extract of Costus igneous managed to recover the condition by its potential anti-oxidative property. Therefore, it might be suggested that insulin plant extract might be used to protect the liver during diabetes.

 

Keywords: Hepatoprotective, melatonin, STZ, Costusigneous

 

Cite this Article

Adyasha Purohit, Seema Rai, Younis Ahmad Hajam et al. Hepatoprotective Role of Exogenous Melatonin and Insulin Plant (Costus IgneousNak.) Extract against the Streptozotocin Induced Diabetes in Rats. Research & Reviews: A Journal of Drug Design & Discovery. 2018; 5(1): 25–36p.

Downloads

Published

2018-07-17

Issue

Vol. 5 No. 1 (2018)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.