Enhancement of Solubility and Dissolution of Ibuprofen by Solid Dispersion Technique with the Help of Box-Behnken Design
Abstract
This study aims to develop a stable solid dispersion of ibuprofen by solvent evaporation technique with increased solubility, dissolution, and stability. Solid dispersion of ibuprofen with PEG-6000 and poloxamer 407 in different weight ratios was prepared using solvent evaporation technique. The saturation solubility study showed a significant effect of all polymers on the solubility of ibuprofen in batch F6, which showed a maximum solubility of 97.99 g/mL in water. The Box-Behnken design was applied to develop the ibuprofen tablet formulation, taking into account poloxamer 407, SSG, and MMC as independent factors, and drug release and compression index as dependent variables.
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Farhana Akter, Mukta Saha, Johura Ansary, study of dissolution characterization of Ibuprofen by different polymers and solid dispersion technique 2015; 6 (4):1528-537.
Zhao. Y, Xin T, Yang X, and Panw, solid dispersion in the development of a nimodipine delayed release tablet formulation 2014; 9(1):35-41
Alladi Saritha, peaveenachary A, Development and characterization of poloxamer solid dispersion of Cefuroxime Axetil 2015; 8(4):360-364.
Digvisha Patel, Dhaval Patel, Physiochemical characterization and in vitro dissolution enhancement of mirabegron using solid dispersion method 2018; 2(12):20-33.
Sreejan manna1, Jyoshna Kola Bathula, Formulation and evaluation of ibuprofen-controlled release matrix tablets using its solid dispersion 2019;11(2):71-76.
Sharma A, Jain C P. Preparation and characterization of solid dispersions of carvedilol with PVP K30 2010;5(1):49-56.
Nadia Saffoon, Yeakuty Marzan Jhanker and Naz Hasan Huda, Dissolution Profile of Ibuprofen Solid Dispersion Prepared with Cellulosic Polymers and Sugar by Fusion Method,201;4(1);31-37.
R Margret Chandira1, Debjit Bhowmik1, Rahul Yadav, B Jayakar, KP Sampath Kumar. Formulation and Evaluation The Oral Tablets Ibuprofen, 2012;9(1):32-42.
Dungarwal UN, Patil SB. Development of Orodispersible Tablets of Taste Masked Rizatriptan Benzoate Using Hydroxypropyl β Cyclodextrin, 2016; 46: 537–545.
Rajendra K. Surawase, Kamalkishor G. Baheti, Box Behnken Design for Optimization of Mirabegron Solid Dispersion by Fluidized Bed Processing, 2022; 15(4):1472-1476.
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