Optimization of Mobile Phase and Stability—Indicating HPTLC Method for the Determination of Prasugrel Hydrochloride in Pharmaceutical Dosage Form

Authors

  • Richa I Champaneria Department of Quality Assurance Maliba Pharmacy College Surat Gujarat
  • Pratik Tailor Department of Quality Assurance Maliba Pharmacy College Surat Gujarat
  • Ashish D Mishra Department of Quality Assurance Maliba Pharmacy College Surat Gujarat
  • Shailesh A Shah Department of Quality Assurance Maliba Pharmacy College Surat Gujarat

DOI:

https://doi.org/10.37591/rrjodfdp.v5i2.132

Keywords:

Key Words, HPTLC Methods, Prasugrel Hydrochloride, Chromatography

Abstract

A simple and sensitive high-performance thin layer chromatographic method was developed and validated for Prasugrel hydrochloride. It was spotted on silica gel 60F254 TLC plates, developed using toluene:methanol (9.9:0.1, v/v) as mobile phase and scanned at 258 nm using a Camag TLC Scanner IV. The Rf value of Prasugrel hydrochloride were found to be 0.53±0.03. It was found to be linear in the concentration range of 300–1500 ng/band. The limit of detection and limit of quantitation for Prasugrel hydrochloride were found to be 300 and 900 ng/band. The proposed method was successfully applied for stability indicating HPTLC method for the determination of Prasugrel hydrochloride in pharmaceutical dosage form.

 

Keywords: Prasugrel hydrochloride, HPTLC

Cite this Article

Champaneria Richa I, Pratik Tailor, Mishra Ashish D et al. Optimization of Mobile Phase and Stability-Indicating HPTLC Method for the Determination of Prasugrel Hydrochloride in Pharmaceutical Dosage Form. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2018; 5(2): 7–12.p.

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Published

2018-10-25

Issue

Vol. 5 No. 2 (2018)

Section

Research Article

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