Synthesis and Chemical Characterization of Novel Series of Benzoxazinone Derivatives

Authors

  • Tuba Khan Student Department of Pharmaceutical chemistry Sultan-ul-uloom College of Pharmacy, Banjara hills, Hyderabad-500034, T.S
  • Y. Rajesh Babu Professor, Department of Pharmaceutical chemistry, Sultan-ul-uloom College of Pharmacy
  • Bibi Fareesa Banu Student Department of Pharmaceutical chemistry Sultan-ul-uloom College of Pharmacy, Banjara hills, Hyderabad-500034, T.S
  • Ausaf Butool Student Department of Pharmaceutical chemistry Sultan-ul-uloom College of Pharmacy, Banjara hills, Hyderabad-500034, T.S

DOI:

https://doi.org/10.37591/rrjodfdp.v5i3.178

Keywords:

Benzoxazinone, Chloroacetylchloride, benzyltriethylammoniumchloride, Bromoethylacetate, Lithiumhydroxide, antibacterial activity

Abstract

The objective of the current work is to synthesize some novel benzoxazinone derivatives and to study their antibacterial activity in particular. Thus an effort has been made in this direction. The antimicrobial activity of the synthesized some novel benzoxazinone derivative is summarized.As estimated, benzoxazinone derivatives exhibited significant to moderate antimicrobial activity. Therefore, a detailed study of toxicity is necessary. Heterocycles formed the sites of reactions in many enzymes or co-enzymes. Among the wide variety of heterocycles that have been discovered for developing pharmaceutically important molecule 1,4-benzoxazines constitute an important group due to their varied variety of biological activities.The anti-microbial testing showed that few compounds have promising activity at low dosage levels. The 2H-benzo[b][1,4]oxazin-3(4H)-one and 3,4-dihydro-2H-1,4-benzoxazinone have been often utilized as suitable skeletons for the design of biologically active compounds. Structures of the newly synthesized compound were established by elemental analysis and spectral data.

 

Keywords: Benzoxazinone, chloroacetylchloride, benzyltriethylammoniumchloride, bromoethyl acetate, lithium hydroxide, antibacterial activity


Cite this Article

Tuba Khan, Rajesh Babu Y, Bibi Fareesa Banu, et al. Synthesis and Chemical Characterization of Novel Series of Benzoxazinone Derivatives. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2018; 5(3): 41–57p.


Downloads

Published

2019-01-30

Issue

Vol. 5 No. 3 (2018)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.