A Factorial Study on the Evaluation of the Effects of Starch, PVP and PEG 6000 on the Dissolution Rate of Pioglitazone Solid Dispersions

Authors

  • P. Mounika gautham college of pharmacy

DOI:

https://doi.org/10.37591/rrjodfdp.v6i1.242

Keywords:

pioglitazone, factorial study, PEG6000, pvp, stacrch

Abstract

Pioglitazone, a relatively new oral anti-diabetic drug belongs to BCS class II with low solubility and high permeability, and as such exhibits low and variable oral bioavailability. It needs enhancement in solubility and dissolution rate for improving its oral bioavailability and consequent reduction in dose. The specific objectives of the study are 1. To evaluate starch as a carrier for enhancing the dissolution rate of pioglitazone, a BCS class II drug. 2. To evaluate the individual and the combined effects of starch, PVP and PEG 6000.

 

Keywords: Pioglitazone, factorial study, starch, PVP, PEG6000

 

Cite this Article

Mounika P. A Factorial Study on the Evaluation of the Effects of Starch, PVP and PEG 6000 on the Dissolution Rate of Pioglitazone Solid Dispersions. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2019; 6(1): 18–24p.

Downloads

Additional Files

Published

2019-05-13

Issue

Vol. 6 No. 1 (2019)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.