Formulation of Vancomycin Capsules and Characterization of Related Substances

Authors

  • CS Srinivas Deparment of Pharmaceutics, Bundelkhand University, Jhansi, U.P., India
  • SB Puranik Deparment of Pharmaceutics, Bundelkhand University, Jhansi, U.P., India

DOI:

https://doi.org/10.37591/rrjodfdp.v2i3.332

Abstract

Aim of this research work was to develop vancomycin capsules and analysis of the related substances which was performed using HPLC and mass spectrometer. The impurities present in the formulation were identified and the two unknown impurities present at RRT about 0.65 and 2.10, were isolated, purified and characterized. The first impurity was found to be a polar substance and it was found to arise due to the amide cleavage of doubly protonated ion originating from vancomycin and PEG. The second impurity was identified as a non-polar substance and the mass spectrum had three peaks corresponding to the doubly protonated ion originating from vancomycin, singly protonated ion from the drug and also due to the bond cleavage between glucopyranose and six member ring. Thus, this study illustrated the unknown impurities present in the vancomycin capsules and has thrown some light on its source of origin.

 

Keywords: Vancomycin capsules, HPLC, mass spectrometer, related substances

 

Cite this Article

Srinivas CS, Puranik SB. Formulation of vancomycin capsules and characterization of related substances. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2015; 2(3): 42–51p.

Downloads

Published

2019-02-27

Issue

Vol. 2 No. 3 (2015)

Section

Review Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.