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Formulation and Evaluation of Microencapsulated Levofloxacin Gel

Snigdha Pattnaik, Sukanya Priyadarshini, Partha Niyogi, Laxmidhar Maharana


To treat various buccal infectious diseases, a sustained release microencapsulated levofloxacin gel was formulated. Levofloxacin microspheres were being prepared following o/w emulsion solvent evaporation technique by varying concentrations of ethyl acetate, ethyl cellulose and tween 80. Depending on their flow properties almost all the microspheres were found to be excellent. The drug-excipient compatibility study carried out using Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC) resulted that the excipients used in the formulation are compatible to the drug used and with each other. However, the microspheres containing 2 g of drug in composition with 1.5% and 1.75% ethyl cellulose, 0.9% and 1% ethyl acetate, respectively, with 4% acetone were found to have more than 50% of drug-loading efficiency, hence optimized for further study. Finally, the optimized microspheres were incorporated within a conventional gel containing varying concentration of carbopol-934P. Conclusively, the optimized microcapsule-loaded gel formulations were evaluated for their physicochemical characters such as pH, viscosity and in vitro release study. All the optimized levofloxacin containing microcapsule-loaded gel formulations were found to possess desired pH and viscosity. Further, the in vitro drug release study showed that the levofloxacin containing microcapsule-loaded gel with 0.45% carbopol-934p was found to be the best formulation.

Keywords: Microcapsulated gel, levofloxacin, FTIR, DSC, in vitro drug release

Cite this Article

Pattnaik S, Priyadarshini S, Niyogi P, et al. Formulation and Evaluation of Microencapsulated Levofloxacin Gel. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2016; 3(1): 39–47p.

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