Comparative Study between Aspirin and Vanadium-Aspirin Complex against Nicotine Exacerbated Diabetic Cataract in Rodents

Abstract

Aspirin is one the most common nonsteroidal anti-inflammatory drug (NSAID) used for the management of various disorders. In the 2254 various previous studies, it was found out that aspirin had a positive correlation in the management of diabetes as well as the cataract. Vanadium is well known metal complex that had an insulin mimetic property and had a significant anti-cataract action. Current work is done with rationale of evaluating the anti-cataract efficacy of Vanadium-Aspirin metal complex (VASCOM) against insulin mimetic cataract against the aspirin alone. A pilot cross sectional observational study had been performed to analyze the feasibility of the experimental work to be performed next, the result of this study shows results which helps to conclude that need of a novel molecule for management of diabetic cataract exacerbated which has higher patient compliance as well as high therapeutic efficacy. Metal complex had been synthesized using Aspirin and VOSO4. The compound had been characterized using IR studies, NMR studies, Magnetic moment studies. Diabetes was induced using fructose and exacerbated by nicotine given subcutaneously. The study took 9 weeks. The Vanadium- NSAID metal complex had given orally in a dose of 20 mg/kg body weight. Antioxidant parameters like MDA, GSH, GPx, and CAT, ions like calcium, polyols and HbA1c levels were evaluated to establish the therapeutic effectiveness of the synthesized complex in diabetic cataract which is exacerbated by nicotine. The hyper insulinemic cataract had been induced by using fructose (20% solution dissolved in drinking water). The exacerbation of the cataract was done using nicotine hydrogen tartar ate. The total time period of the study was 9 weeks. The current works helps us to solve the problem of cataract rationally and a novel system should be explored of the cataract.

Keywords: Diabetic cataract, oxidative stress

Cite this Article

Arin Bhattacharya, Dr. S. H. Bodakhe.  Comparative Study between Aspirin and Vanadium-Aspirin Complex against Nicotine Exacerbated Diabetic Cataract in Rodents. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2017; 4(3): 18–36p.