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A Possible Case of Methotrexate Induced Hepatic Cirrhosis

Harsha R., Vikram Reddy K, Malatesh Undi



A patient with psoriasis on long term methotrexate (MTX) therapy (cumulative dose=14.4 g) developed cirrhosis of liver associated with portal HTN and ascites. All the other possible causes for liver cirrhosis like HBV, HCV infection were ruled out. Investigations: antibodies (LKM-1), anti-mitochondrial antibodies (AMA 1,2,3,4,5,6,7,8,9), anti-treponemal antibody (TPHA), HBS Ag, anti-HCV were negative.


Keywords: methotrexate, psoriasis, cirrhosis

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