A Possible Case of Methotrexate Induced Hepatic Cirrhosis

Authors

  • Harsha R. Clinical Pharmacology Unit, Department of Pharmacology
  • Vikram Reddy K Clinical Pharmacology Unit, Department of Pharmacology
  • Malatesh Undi Departrment of Community Medicine, KIMS, Bangalore, India

Abstract

 

A patient with psoriasis on long term methotrexate (MTX) therapy (cumulative dose=14.4 g) developed cirrhosis of liver associated with portal HTN and ascites. All the other possible causes for liver cirrhosis like HBV, HCV infection were ruled out. Investigations: antibodies (LKM-1), anti-mitochondrial antibodies (AMA 1,2,3,4,5,6,7,8,9), anti-treponemal antibody (TPHA), HBS Ag, anti-HCV were negative.

 

Keywords: methotrexate, psoriasis, cirrhosis

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Published

2021-01-07

Issue

Vol. 3 No. 1 (2013)

Section

Case Study

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