Formulation Evaluation and Optimization of Orodispersible Tablets of Pantoprazole Sodium by the using of Different Superdisintigrants

Authors

  • Chundawat Lokendra Singh Department of Pharmacy, Mandsaur University, Mandsaur M.P.
  • Wadhwa Shailendra Department of Pharmacy, Mandsaur University, Mandsaur M.P.

Abstract

The objective of this study was to formulate and optimize an orodispersible formulation of pantoprazole sodium using a 32 factorial design for optimized the superdisintigrant concentration. Various concentration (2%,4%,6%) of superdisintegrants (SSG, CP) were added in formulation, all processing steps are carried out at temperature below 250C and relative humidity less than 35%. Procedure to manufacture orodispersible tablets by direct compression was established. The results show that the presence of a superdisintegrants is desirable for orodispersion. The best optimized batch found was the batch having amount of crosspovidone 4.37 mg and SSG 10.59 mg. All the formulations satisfied the limits of orodispersion with a dispersion time of less than 30 sec. Best formulation showed a disintegration time of 30 sec, % friability is 0.82%, drug content of 96 to 99.4 and fast drug release rate of 80% of drug release within 10 min. The optimized batch was evaluated for thickness, weight variation, hardness, friability, disintegration time dissolution and accelerated stability study for period of 3 months. The similarity factor was calculated for comparison of dissolution profile before and after stability studies. The f2 value was found more than 50 that indicate a good similarity between both the dissolution profiles. Hence, the results of stability studies reveal that the developed formulation has good stability.

Keywords: Pantoprazole sodium, Orodispersion, Crosspovidone, SSG, Factorial design

Cite this Article Chundawat Lokendra Singh, Wadhwa Shailendra. Formulation Evaluation and Optimization of Orodispersible Tablets of Pantoprazole Sodium by the using of Different Superdisintigrants. Research & Reviews: A Journal of Pharmacology. 2017; 7(3): 11–20p. 

Downloads

Published

2018-01-20

Issue

Vol. 7 No. 3 (2017)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.