Evaluation of Anthelmintic, Analgesic and Neuropharmacological Activity of Merremia hederacea

Authors

  • Fahim Monwar Nazia
  • Sadia Afreen Chowdhury

Abstract

The aim of the present study was to evaluate the phytochemical screening, anthelmintic activity, analgesic properties and neuropharmacological activity of the leaf extract of Merremia hederacea (Family: Convovulaceae). After preliminary phytochemical screening, the leaf extract of Merremia hederacea contain flavonoids, tannins, alkaloids and reducing sugars. Anthelmintic activity test was done by comparing the time of paralysis and the time of death of earthworms Pheretima posthuma compared with the standard drug, Albendazole. The minimum to maximum time of paralysis and death of Albendazole observed at the concentration of 25, 50, 100 mg/ml was 3 min 6 sec to 10 min 23 sec and that for the fresh leaf juice was 45 min 52 sec to 48 min 32 sec, respectively. From experimental data, the fresh juice of the leaf of Merremia hederacea showed mild anthelmintic activity. The analgesic potential of the leaf extract was evaluated using acetic acid-induced writhing, tail immersion and hot plate tests in Swiss albino mice at the doses of 200 and 400 mg/kg body weight. The results of tail immersion and hot plate test showed potential analgesic activity of the extract, which is comparable to the standard drug, Diclofenac-Na (10 mg/kg). The neuropharmacological activity in open field and hole cross was not significant enough. Thus, the results of the present study suggested that the extract possesses significant analgesic activity in mice.

 

Keywords: Merremia hederacea, anthelmintic, analgesic, Neuropharmacological activity, Swiss albino mice

 

Cite this Article

Fahim Monwar Nazia, Sadia Afreen Chowdhury. Evaluation of Anthelmintic, Analgesic and Neuropharmacological Activity of Merremia hederacea. Research & Reviews: A Journal of Pharmacology. 2020; 10(1): 28–33p.

Downloads

Published

2020-05-21

Issue

Vol. 10 No. 1 (2020)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.