A Review on Natural Radio-protective Agents

Authors

  • Smitha Gandra Associate Professor, Department of Pharmaceutics, Marathwada Mitra Mandal’s College of Pharmacy, Thergoan, Pune, India
  • Shilpi Kondaskar Assistant Professor, Department of Pharmaceutical Chemistry, Marathwada Mitra Mandal’s College of Pharmacy, Thergoan, Pune, India
  • Swapna Gawai Student, Department of Pharmaceutics, Marathwada Mitra Mandal’s College of Pharmacy, Thergoan, Pune, India

Abstract

Abstract

Radioprotectors play crucial role in safeguarding biological system from various damages to DNA (Deoxyribonucleic acid), protein molecules, lipids by peroxidation as well as hematopoietic, gastrointestinal, reproductive and central nervous system exposed to radiation dose especially against radiation injury in cancer survival patients undergoing radiotherapy. As over 40% patients require this therapy, during the treatment where ionizing radiation is used to shrivel tumors and exterminate cancer cells by disrupting their DNA. The present review intimately chronicles the rich intellectual, pharmacological story of natural radioprotectors. In this article, for the first time we have discussed the impact of radioprotectors on different signaling pathways in cells, which will create a basis for scientific community working in this area to develop novel molecules with better therapeutic efficacy. Therefore to enhance therapeutic ratio (ratio of cancer killing cells to normal cells toxicity with the given dose) radioprotective agents are gaining significant interest.

 

Keywords: Applications, examples, mechanism of action, natural radio-protective agents, pharmacology

Cite this Article

Smitha Gandra, Shilpi Kondaskar, Swapna Gawai. A Review on Natural Radio-protective Agents. Research & Reviews: A Journal of Pharmacology. 2020; 10(2): 20–31p.


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Published

2020-09-22

Issue

Vol. 10 No. 2 (2020)

Section

Review Article

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