Synthesis and Anti - Inflammatory Activity of A Novel Series of Quinoxaline2, 3-Dione Derivatives

Abstract

Aim: The aim of the present study is to synthesis and screening the anti-inflammatory effect of novel series of quinoxaline 2, 3Dione derivatives containing a 4-thiazolidinone (T1-T5) nucleus. Method: Thesynthesis of thiazolidinones by reacting N-substituted arylidene/heteroarylidene Quinoxaline 2, 3-dione with thioglycollic acid in the presence of dry benzene. All the title compounds were tested for their anti-inflammatory activity of the synthesized compounds was evaluated by Carrangeenan induced paw edema method in rats. The activity was studied at 200 and 400 mg/kg b. w., p.o. and their effects were measured at 30, 60, 120 and 180 min. Result: Anti-inflammatory activity of synthesized compounds was tested by Carrangeenan induced paw edema method in rats standard drug used for the study was Diclofenac sodium. The methoxy, chloro and bromo substitution in three derivatives showed significant anti-inflammatory activity when compared to standard. The hydroxy, nitro groups showed mild activity when compared to standard. Conclusion: A novel series of quinoxaline 2,3- Dione derivatives has anti-inflammatory activity so supplementary exploration has been needed to establish other pharmacological performance of these derivatives and in future it would be a most promising and leading derivatives for several ailments

Keywords: Anti-inflammatory activity, Quinoxaline2, 3-Dione, Schiff bases reactions, thiazolidinones.

Cite this Article

E. Sankari, Sandhiya V., Anamika P.K. Synthesis and Anti - Inflammatory Activity of A Novel Series of Quinoxaline2, 3-Dione Derivatives. Research & Reviews: A Journal Pharmaceutical Science. 2020; 11(3): 7–13p.