Synthesis and Anti - Inflammatory Activity of A Novel Series of Quinoxaline2, 3-Dione Derivatives

Authors

  • E. Sankari assistant professor, c.l.baid metha college of pharmacy
  • Sandhiya V.
  • Anamika P.K.

Abstract

Aim: The aim of the present study is to synthesis and screening the anti-inflammatory effect of novel series of quinoxaline 2, 3Dione derivatives containing a 4-thiazolidinone (T1-T5) nucleus. Method: Thesynthesis of thiazolidinones by reacting N-substituted arylidene/heteroarylidene Quinoxaline 2, 3-dione with thioglycollic acid in the presence of dry benzene. All the title compounds were tested for their anti-inflammatory activity of the synthesized compounds was evaluated by Carrangeenan induced paw edema method in rats. The activity was studied at 200 and 400 mg/kg b. w., p.o. and their effects were measured at 30, 60, 120 and 180 min. Result: Anti-inflammatory activity of synthesized compounds was tested by Carrangeenan induced paw edema method in rats standard drug used for the study was Diclofenac sodium. The methoxy, chloro and bromo substitution in three derivatives showed significant anti-inflammatory activity when compared to standard. The hydroxy, nitro groups showed mild activity when compared to standard. Conclusion: A novel series of quinoxaline 2,3- Dione derivatives has anti-inflammatory activity so supplementary exploration has been needed to establish other pharmacological performance of these derivatives and in future it would be a most promising and leading derivatives for several ailments

 

Keywords: Anti-inflammatory activity, Quinoxaline2, 3-Dione, Schiff bases reactions, thiazolidinones.

 

Cite this Article

E. Sankari, Sandhiya V., Anamika P.K. Synthesis and Anti - Inflammatory Activity of A Novel Series of Quinoxaline2, 3-Dione Derivatives. Research & Reviews: A Journal Pharmaceutical Science. 2020; 11(3): 7–13p.

Downloads

Published

2021-01-07

Issue

Vol. 11 No. 3 (2020)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.