Comparative Evaluation of Corneal Permeation of Indomethacin Using Different Vegetable Oil

Authors

  • Arun Raj. R Assistant Professor, Department of Pharmaceutical Sciences (RIMSR), Centre for Professional and advanced studies, Kottayam-9, Kerala, India
  • Lorain Mary Jose PG Scholar, Department of Pharmaceutical Sciences (RIMSR), Centre for Professional and advanced studies, Kottayam-9, Kerala, India

Keywords:

Indomethacin, Permeation, Arachis oil, Castor oil, Linseed oil, Partition.

Abstract

Topical administration of drugs is the most favoured route for management of ocular inflammation. About 90% of dose applied topically from such solutions is lost due to precorneal losses (nasolacrimal drainage) and tearing results in poor availability as contact time is less between drug and ocular tissue. An increased ocular contact time of the drug may be achieved by formulating the drug as an oil solution. In this study, invitro permeation of indomethacin from oil drops were studied in arachis, castor and linseed oil. Partition behaviour studies in each oil with and without benzyl alcohol were conducted and based on partition study a suitable oil was selected for further evaluation. Based on partition value of Indomethacin in each oil, comparatively partition in arachis oil with benzyl alcohol showed better results compared to castor and linseed oil with and without benzyl alcohol. Invitro studies of Indomethacin in arachis oil (both 0.5%w/v and 1%w/v) was performed. Increased permeation was obtained in 1%w/v Indomethacin drops in arachis oil with benzyl alcohol compared to 0.5%w/v Indomethacin drops in arachis oil with benzyl alcohol. The amount permeated was found to be maximum with Indomethacin 1%w/v (0.092 mg or 0.09%) solution in arachis oil than in 0.5%w/v (0.042 mg or 0.084%) and the addition of Benzyl alcohol to oil drops increases drug permeation due to an increased partitioning of the drug in the aqueous phase.

References

Chien YW. Novel Drug Delivery Systems. 2nd Edition. New York: Marcel Dekker Inc; 1992. P: 269-272.

Arun Raj R, Abhiram A. Development and Characterization of Ion-Activated Ocular in situ Gel of Carbinoxamine Maleate. Res Rev A J Pharm Sci. 2019;10(1):1–7.

Burdock GA, Carabin IG, Griffith JC Toxicology and pharmacology of sodium ricinoleate. Food Chem Toxicol. 2006:44; 1689-1698

Williams RN, Bhattacherjee P, Eakins KE. Biosynthesis of lipoxygenase products by ocular tissues. Exp Eye Res 1983; 36: 397–402.

Arun Raj.R JH. Enhancement of bioavailability of carvedilol using solvent deposition techniques. Int J Pharm Sci Res. 2017;8(8):3391–401.

The United States Pharmacopoeia 28 NF; Asian edition; United States Pharmacopoeial convention; P.no.180; (2005).

Ainley Made, Paul J.Weller, Hand book of pharmaceutical excipients; 2nd edition; P.no.-519 (1994).

Ajit kumar, Dipak Kanti Majumdar, Gitanjali Mishra. Invitro corneal permeation of Etoricoxib from oil drops. Asian Journal Pharmaceutics. 2018; 12(4): 208–212.

Weber M, kodjikian L, Allaire CM. Efficacy and safety of indomethacin 0.1% eye drops compared with ketorolac 0.5% eye drops in the management of ocular inflammation after cataract surgery. Acta Opthalmol.2013; 91(1): 175–376.

Malhotra M, Majumdar DK. Invitro transcorneal permeation of Ketorolac from oil based ocular drops and ophthalmic ointment. Indian J Exp Biol. 1997; 35(12): 1324–30.

Arun Raj R, Murali A. Formulation and Evaluation of Curcumin Loaded Transferosomal Nasal In-Situ Gel for Alzheimer’s Disease. Res Rev A J Drug Formul Dev Prod. 2019;6(2):19–31.

Munish Ahuja, Surendra Kumar Sharma and Dipak Kanti Majumdar. Invitro corneal permeation of diclofenac from oil drops. Yakugaku Zasshi. 2017; 127(10): 1739–1745.

Ajit kumar Acharya, Dipak Kanti Majumdar, Gitanjali Mishra. Invitro corneal permeation of Celecoxib from oil drops. International Journal Research and Development in Pharmacy and Life sciences. 2015; 5(1): 1955–1962.

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Published

2021-09-15

Issue

Vol. 12 No. 2 (2021)

Section

Research Article

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