Progress in Pharmacological Potential of Thione Substituted 1,3,4-Thiadiazoles: A Review

Authors

  • N.S. Mahajan Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola, Solapur-413307, Maharashtra, India
  • S.C. Dhawale School of Pharmacy, SRTM University, Nanded, Maharashtra, India
  • P.N. Khatale School of Pharmacy, SRTM University, Nanded, Maharashtra, India
  • S. T. Bhosale Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola, Solapur-413307, Maharashtra, India

DOI:

https://doi.org/10.37591/(rrjops).v3i2.938

Abstract

 

Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. From the last decade, good research is going on the 1,3,4-thiadiazole ring, as a result of which, many research groups has developed novel clinically useful compounds. These compounds had shown its importance as anti-inflammatory, analgesic, antimicrobial, antitumor, antifungal, antimycobacterial, anticonvulsant, antidiabetic, antiviral agents etc. So far, the modifications of the 1,3,4-thiadiazole ring has proven highly effective way to find medicinally useful compounds with improved potency and less toxicity. The present review highlights the pharmacological importance of thione substituted 1,3,4-thiadiazol derivatives. This review also discusses the structure-activity relationships of the most potent compounds. It can act as an important tool for medicinal chemists to develop newer compounds possessing 1,3,4-thiadiazole moiety that could be better agents in terms of efficacy and safety.

Keywords: 1,3,4-Thiadiazole, Anti-microbial, Antitubercular, Anticancer, Anticonvulsant

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Published

2021-01-14

Issue

Vol 1-3, No 2 (2010-12)

Section

Research Article

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