A PROSPECTIVE STUDY ON HEMOVIGILANCE AND BLOOD TRANSFUSION SAFETY PRACTICES – IMPACT OF CLINICAL PHARMACIST.
Abstract
AIM & BACKGROUND:Blood Transfusions are lifesaving intervention but are associated with
potential to cause adverse events. The present study is conducted to track ATR’s patterns associated with
blood and blood products and generate evidence-based recommendations and to promote optimal blood
usage.
METHODS & MATERIALS: The present study is a prospective, observational and interventional study
conducted over a period of 10 months at ESI hospital, Indiranagar. About 90 patients undergoing
transfusions were selected for the study. Forms, Case sheets, Treatment charts were used to collect the
data. Descriptive statistics & Prism graph software was used to analyse the data collected.
RESULTS:Among the 90 participants in the study51 (56.66%) were found to be females and 39
(43.33%) were males. Patients in this age range made up the most people overall.30-40 accounting for
28.8% (26) followed by the least no of patients were in the 20-30 and 70-80(7.7%) age group
respectively. Majority of Indications for blood transfusion was made for Anaemia accounting for 47.7%
(43). Whereas minimum indication was made for cardiac related cases accounting for 2 (2%). A total of
208 transfusions were done during the study period, in which PRBC’S were majorly transfused
136(65.38%) followed by Platelets 34 (16.3%). About 24 Transfusion reactions were reported in study
population, the PRBC’s 66.6% (16) contributed to the greater number of transfusion reactions in
comparison with Platelets 12.5% (03). The distribution of nature of adverse events showed Anaphylactic
reactions 06 (25%) with highest followed by DHTR 01 (4.1%) to be the lowest. About 12(50%)
transfusion reactions were of Grade 1, followed by 09(37.5%) transfusion reactions were of Grade 2, 03
(12.5%) transfusion reactions of Grade-3 & no reactions reported were of Grade4 severity respectively.
In order to manage the transfusion reaction highest cases were managed by Anti-histamines, Antipyretics,
Vasopressors followed by least caseswere managed by Antibiotics and Anti-emetic.
CONCLUSION: The active role of Clinical pharmacist in reporting transfusion reactions can help in
policy making by identifying trends. Evidence based recommendations can be generated from transfusion
reports leading to more informed decisions from the clinician’s end. Ensuring better outcomes for the
patients undergoing transfusions.
Keywords
Full Text:
PDFReferences
Shander A, Nemeth J, Cruz JE, Javidroozi M. Patient blood management: A role for pharmacists.
Am J Health Syst Pharm [Internet]. 2017;74(1): e83–9. Available from:
http://dx.doi.org/10.2146/ajhp151048
de Vries RRP, Faber J-C, Strengers PFW, Board of the International Hemovigilance Network.
Hemovigilance: an effective tool for improving transfusion practice: Hemovigilance. Vox Sang
[Internet]. 2011;100(1):60–7. Available from: http://dx.doi.org/10.1111/j.1423-
2010.01442.x
World Health Organization. A guide to establishing a national hemovigilance system. Genève,
Switzerland: World Health Organization; 2017
Boparai JK, Singh S. Hemovigilance: A new beginning in India. Int J Appl Basic Med Res
[Internet]. 2015;5(3):200–2. Available from: http://dx.doi.org/10.4103/2229-516X.165379
Sreekumar PK. Hemovigilance in India - A Milestone in Transfusion Safety.
Mukherjee S, Maiti R. Hemovigilance: A current update in Indian perspective. J ClinDiagn Res
[Internet]. 2016;10(11):EE05–9. Available from:
http://dx.doi.org/10.7860/JCDR/2016/21029.8868
International journal of pharmaceutical sciences and research. Vol. 11. International Journal of
Pharmaceutical Sciences and Research; 2020.
Sukanta Sen1*, Dr. Pankaj Gupta 2 , Dr. Satwika Sinha 3 , Dr. PawanBhambani. Hemovigilance and
Transfusion Safety: A Review. Scholars Journal of Applied Medical Sciences (SJAMS).
;2(1A):85–90
. https://www.who.int/news-room/fact-sheets/detail/blood-safety-and-availability
. https://www.ncbi.nlm.nih.gov/books/NBK138219/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868404/#:~:text=Premedication%20with%20ac
etaminophen%20and%20diphenhydramine,in%20the%20US%20and%20Canada
Dr. Prasanna, Ganpisetti DRR, Susmitha DRG. To track adverse reactions, events and incidence
associated with blood and blood product transfusion: Pharmaceutical science-medicine. Int J Life
Sci Pharma Res [Internet]. 2019;9(3). Available from:
http://dx.doi.org/10.22376/ijpbs/lpr.2019.9.3.p48-60
Koch CG, Li L, Sessler DI, Figueroa P, Hoeltge GA, Mihaljevic T, et al. Duration of red-cell
storage and complications after cardiac surgery. N Engl J Med [Internet]. 2008;358(12):1229–39.
Available from: http://dx.doi.org/10.1056/NEJMoa070403
DOI: https://doi.org/10.37591/tdd.v9i3.1228
Refbacks
- There are currently no refbacks.
Copyright (c) 2023 Trends in Drug Delivery