Microsphere: A Novel Drug Delivery System Approach

Abstract

Microspheres are the multiarticulate novel drug delivery dosage form, it contains the particle size range from 1 to 50 µ and characteristically spherical in shape with free flow property. It is widely known as “Microparticles”. Microspheres are prepared by covering the drug particles with polymeric solution (obtained in natural, semisynthetic or synthetic form) to achieve controlled release of drug, which produces prolonged action with reduced toxicity at the specified site in the biological system. In current decades, the manufacturing techniques of microspheres are handled with multiple techniques for producing site-specific action, improved efficacy of drug, patient convenient and mainly reduced toxicity. The techniques are known as Coacervation technique (CP), Solvent evaporation, Spray drying, Spray congealing, Phase separation, Emulsion techniques (single emulsion & double emulsion). The present review highlights several carriers used in the preparation and evaluation of microspheres, their release mechanisms, merits, demerits and applications.

Keywords: Microspheres, novel drug delivery system (NDDS), microparticles, preparation techniques, evaluation of microspheres

Cite this Article

Senthamil Selvan T. Microsphere—A Novel Drug Delivery System Approach. Trends in Drug Delivery. 2019; 6(1):
24–30p.