Formulation and Evaluation of Transdermal Drug Delivery of Piroxicam

Authors

  • Mudit Dixit Department of Pharmaceutics, NGSM Institute of Pharmaceutical sciences, Nitte University, Mangalore, Karnataka, India
  • P. K. Kulkarni Department of Pharmaceutics, J.S.S College of pharmacy, J.S.S University, Mysore, India
  • R Narayana Charyulu Department of Pharmaceutics, NGSM Institute of Pharmaceutical sciences, Nitte University, Mangalore, Karnataka, India

DOI:

https://doi.org/10.37591/tdd.v1i2.263

Abstract

The aim of the present study was to formulate transdermal films loaded with Piroxicam (PX). Transdermal films were prepared by using sodium alginate (SA) and xanthan gum (XG) as biopolymers by varying the blend ratios viz., 10:0, 8:2, 6:4, 4:6 and 2:8 (w/w %) through solution casting method. The drug loaded membranes were evaluated for thickness, tensile behaviours, and content uniformity. In-vitro diffusion was determined by Franz diffusion cell. Piroxicam was found to be compatible and stable with the prepared formulation as confirmed by Fourier transform infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC), studies. Invitro release studies revels effectiveness after 24 h. The study results suggest that biopolymer based Transdermal films are potential vehicles for improved transdermal delivery of PX for effective therapy.

 

Keywords: Piroxicam, Sodium alginate, Xanthan gum, Transdermal release, Skin permeation

Downloads

Published

2019-03-19

Issue

Vol. 1 No. 2 (2014)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.