Formulation and Evaluation of Transdermal Drug Delivery of Piroxicam

Abstract

The aim of the present study was to formulate transdermal films loaded with Piroxicam (PX). Transdermal films were prepared by using sodium alginate (SA) and xanthan gum (XG) as biopolymers by varying the blend ratios viz., 10:0, 8:2, 6:4, 4:6 and 2:8 (w/w %) through solution casting method. The drug loaded membranes were evaluated for thickness, tensile behaviours, and content uniformity. In-vitro diffusion was determined by Franz diffusion cell. Piroxicam was found to be compatible and stable with the prepared formulation as confirmed by Fourier transform infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC), studies. Invitro release studies revels effectiveness after 24 h. The study results suggest that biopolymer based Transdermal films are potential vehicles for improved transdermal delivery of PX for effective therapy.

Keywords: Piroxicam, Sodium alginate, Xanthan gum, Transdermal release, Skin permeation