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Fabrication and Assessment of Gallic Acid as Novel Drug Carrier

V. Sandhiya, M. Shree Krishna, V. Raja


Objective: The purpose of the current investigation is to develop and evaluate the polymer-based microspheres to overcome the issues of frequent dosing and high first pass metabolism. Materials and Methods: Gallic acid loaded microsphere were prepared by solvent evaporation technique and the microspheres were evaluated for drug entrapment efficiency, drug loading efficacy, particle size, In-vitro drug release, surface morphology and FTIR spectroscopy studies. Results: The percentage yield, drug entrapment and swelling studies show reasonable results. The microsphere was spherical with smooth surface. The FTIR spectra shows that there was no potential interaction between the drug and the polymer. Conclusion: The data obtained from the above studies revealed that the drug loaded microsphere could be considered as a potential delivery system to maintain the plasma concentration of drug to elicit its pharmacological action.

Keywords: Gallic acid, Solvent evaporation method, hydrophobic polymer.

Cite this Article

V. Sandhiya, M. Shree Krishna, V. Raja. Fabrication and Assessment of Gallic Acid as Novel Drug Carrier. Trends in Drug Delivery. 2019; 6(2): 5–10p.

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Kumar A, Jha S, Rawal R, Chauhan PS, Maurya SD. Mucoadhesive microspheres for novel drug delivery system: A Review. American J Pharm Tech Res 2013;3(4):197-213.

Batra D, Kakar S, Singh R.Magnetic microspheres as a targeted drug delivery system: An overview. J drug deli res 2012;1(3):1-17.

Parmar Harshad, Bakliwal, Sunil at al. Different Method of Evaluation Of Mucoadhesive Microsphere. Int J Applied Bio Pharma Tech 2010;1(3):1164-1165.

Agusundaram M, Madhu Sudana Chetty et al. Microsphere As A Novel Drug Delivery System A Review. Int J Chem Tech Res. 2009;1(3):526-534.

Bhaskar Mazumder B. Preparation and in vitro evaluation of chlorpheniramine maleate loaded microspheres. Int. J. Pharm Tech Res 2013;1(3): 905-913.

Lin W J. Preparation and evaluation of venlafaxine HCL microsphere Microencapsulation. Int J Chem Tech Research 2001;8(5): 559-565.

Chandy S Rail, Suresh Sahu. Formulation and in-vitro studies of aceclofenac microsphere. J Pharma. Dosage Forms Tech 2009;1(1):29-32.

Deore B. Formulation and evaluation of indomethacin microsohere. Int J of Chem Tech Res. 2004;1(3): 634-642.



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