Formulation and Evaluation of Curcumin Microspheres

Abstract

Purpose: To prepare and evaluate curcumin microspheres to improve the absorption and bioavailability of the drug. Methods: Curcumin microspheres were prepared by solvent evaporation method, by using hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios of 1:1, 1:2, 1:3 by using ethanol/dichloromethane as the solvent. The prepared microspheres were evaluated for percentage yield, flow properties, entrapment efficiency, drug content, drug loading, particle size analysis, drug release, surface morphology and release kinetics. Result: The curcumin microspheres showed yield, drug content, drug entrapment efficiency and particle size in the ranges of 17‑86%, 37.4‑78.9%, 80.6‑98.4% and 10‑28 µm respectively. Maximum drug release after 24 h was 98.32% for F-4 formulation. Conclusion: The formulated curcumin microspheres enhanced the bioavailability and also sustained the release of curcumin.

Keywords: bioavailability, Curcumin microspheres, ethyl cellulose, Eudragit S100, hydroxylpropyl methylcellulose

Cite this Article

S. Dhivya, A.N. Rajalakshmi. Formulation and Evaluation of Curcumin Microspheres. Trends in Drug Delivery. 2019; 6(3):
1–11p.