Microneedles: A New Concept for Transdermal Drug Delivery

Abstract

Transdermal delivery keeps a promising carrier in the transport of drugs which get direct access across the skin deep into the systemic circulation. Advantages of transdermal drug delivery system include improved patient compliance, less dose of biologicals, avoidance of gastric irritation as well as the elimination of the first-pass metabolism. Microneedles can be used to improve transdermal drug delivery for some drugs. In this study, we focus on methods of fabrication and applications of microneedles being highlighted. Microneedles can be inserted in body in many forms like, hollow, solid and dissolving. Hydrogen forming gel is another form of microneedles. Hydrogen forming gel has attracted many researchers due to various biomedical advantages. It is an innovative microneedle which does not contain drugs. The regulatory authority has approved several MNs for their clinical use and examination. The last part of this review discusses concerns and challenges with microneedles.

Keywords: Dissolving microneedles, drug delivery, hydrogel-forming microneedles, microneedles, transdermal

Cite this Article

Monika Rameshwar Rambhad, Chitra Sureshrao Paytode, Vinod Madhaorao Thakare. Microneedles: A New Concept for Transdermal Drug Delivery. Trends in Drug Delivery. 2019; 6(3): 22–29p.