Formulation and Evaluation of Microballoons of Ramipril

Authors

  • Sonam M Gandhi Assistant professor Maliba Pharmacy College Surat, Gujarat India
  • Bhumika Patel Assistant professor Maliba Pharmacy College Surat, Gujarat India
  • Roopa Karki Assistant professor Maliba Pharmacy College Surat, Gujarat India
  • Atit Pandey Assistant professor Maliba Pharmacy College Surat, Gujarat India
  • Divakar Goli Professor, Maliba Pharmacy College, Surat, Gujarat, India
  • Kanchan Singh Assistant professor Maliba Pharmacy College Surat, Gujarat India

DOI:

https://doi.org/10.37591/rrjodfdp.v5i2.115

Keywords:

Microballoons, Ramipril, Eudragit E100, HPMC K4M, Emulsion solvent evaporation method, Stability study.

Abstract

The present study was an attempt to develop microballoons of Ramipril to prolong gastric residence time in stomach and to control drug release in therapeutic range. Ramipril is ACE inhibitor having short half-life of 2–4 h and bioavailability 28%. Microballoon was formulated using Eudragit E100 and HPMC K4M in different ratios by emulsion solvent evaporation technique using methanol as evaporating solvent and liquid paraffin as a processing medium. Microballoons were characterized for micromeritic properties, drug entrapment efficiency, in vitro buoyancy, drug polymer compatibility study, scanning electron microscopy and in vitro release studies. Microballoons were white, free flowing and spherical in shape. It showed 53.23–86.03% of entrapment and release extended up to 12 h. Two months of stability study was carried out at 30±2°C (65±5%RH) for best F8 formulation which showed no significant changes in % drug entrapment efficiency and in vitro release study.

 

Keywords: Microballoons, Ramipril, Eudragit E100, HPMC K4M, emulsion solvent evaporation method, stability study

Cite this Article

Gandhi Sonam M, Bhumika Patel, Roopa Karki, et al. Formulation and Evaluation of Microballoons of Ramipril. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2018; 5(2): 13–30p.

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Published

2018-10-31

Issue

Vol. 5 No. 2 (2018)

Section

Research Article

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