Enhancement of Solubility and Dissolution of Ibuprofen by Solid Dispersion Technique with the Help of Box-Behnken Design

Authors

  • Sake Vaishnavi S. Research Scholar, Department of Pharmaceutics, Shri Gurudatta Shikashan Santha´s Loknete Dr. J. D Pawar College of Pharmacy, Manur, Nashik, Maharashtra, India
  • Rajendra Surawase Professor, Department of Pharmaceutics, Shri Gurudatta Shikashan Santha´s Loknete Dr. J. D Pawar College of Pharmacy, Manur, Nashik, Maharashtra, India
  • Narote sudam R Research Scholar, Department of Quality Assuarance, Shri Gurudatta Shikashan Santha´s Loknete Dr. J. D Pawar College of Pharmacy, Manur, Nashik, Maharashtra, India
  • Shruti Raundal Research Scholar, Department of Pharmaceutics, Shri Gurudatta Shikashan Santha´s Loknete Dr. J. D Pawar College of Pharmacy, Manur, Nashik, Maharashtra, India
  • Borse Sudarshan Research Scholar, Department of Pharmaceutics, Shri Gurudatta Shikashan Santha´s Loknete Dr. J. D Pawar College of Pharmacy, Manur, Nashik, Maharashtra, India
  • Mayur Sonawane Research Scholar, Department of Pharmaceutics, Shri Gurudatta Shikashan Santha´s Loknete Dr. J. D Pawar College of Pharmacy, Manur, Nashik, Maharashtra, India

Keywords:

Ibuprofen solid dispersion, factorial design, solvent evaporation technique, bioavaibility

Abstract

This study aims to develop a stable solid dispersion of ibuprofen by solvent evaporation technique with increased solubility, dissolution, and stability. Solid dispersion of ibuprofen with PEG-6000 and poloxamer 407 in different weight ratios was prepared using solvent evaporation technique. The saturation solubility study showed a significant effect of all polymers on the solubility of ibuprofen in batch F6, which showed a maximum solubility of 97.99 g/mL in water. The Box-Behnken design was applied to develop the ibuprofen tablet formulation, taking into account poloxamer 407, SSG, and MMC as independent factors, and drug release and compression index as dependent variables.

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Published

2022-08-29

Issue

Vol. 9 No. 2 (2022)

Section

Research Article

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