In-Vitro Evaluation of Extended Release Atorvastatin Tablets by using Natural Gums

Authors

  • P. Venkatesh Assistant Professor, Department of Pharmaceutics, Sri Indu Institute of Pharmacy, Sheriguda, Telangana, India
  • S. K. Godasu Assistant Professor, Department of Natural Products, Sri Indu Institute of Pharmacy, Sheriguda, Telangana, India
  • G. S.V. Divya Jyothi Assistant Professor, Department of Pharmacology, Sri Vishnu College of Pharmacy, Kovvada, Andhra Pradesh, India
  • V. Rajashakar Assistant Professor, Department of Medicinal Chemistry, Anurag Pharmacy Collage, Ananthagiri, Kodad, Telangana, India

DOI:

https://doi.org/10.37591/rrjodfdp.v6i2.561

Abstract

The present research is the formulation of extended-release tablets Atorvastatin is used as a hypoglycemic agent; it is HMG CoA Reductase inhibitor. All the formulation were prepared with using different grades of xanthan gum, guar gum, sodium alginate, then all the formulations were subjected to pre-compression and post-compression parameters such as angle of repose, bulk density, tapped density, Carr’s index, Hausner's ratio, weight variation, thickness, hardness, friability and drug content. All the formulations were showed within IP specifications. Total weight of the tablets was considered as 200 mg. The “9” formulations were carried out in-vitro drug release studies. Among all the formulations “F6” formulation containing guar gum was showed a maximum percentage of drug release up to 12 hours. So, this is the optimized formula and applied release kinetics to optimized formula, and it followed zero-order release kinetics.

Keywords: Atorvastatin, extended-release tablets, natural gums

Cite this Article

P. Venkatesh, S. K. Godasu, G.S.V. Divya Jyothi, V. Rajashakar. In-Vitro Evaluation of Extended Release Atorvastatin Tablets by using Natural Gums. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2019; 6(2): 55–62p.

References

REFERENCES:

Sathish Ummadi, B. Shravani et al. Overview On Controlled Release Dosage Form. International Journal Of Pharma Sciences, 2013; 3(4): 258-269

Marleen Schonewille, Jan Freark De Boer et al. Statins Increase Hepatic Cholesterol Synthesis And Stimulate Fecal Cholesterol Elimination In Mice. Journal Of Lipid Reaserch, 2016; 57(8): 1455–1464

Handbook of Modern Pharmaceutical Analysis Edward Lau, In separation science and technology, 2001

Final text for addition to the international pharmacopoeia, World health organization , 2012

Birtok. A. Oral And Formulated Pharmaceutical preparations before The invention of Tablets. 2009; 55(14):171-82

Daljit Masih1, Rajesh Gupta, Formulation And Evaluation Of Mouth Dissolving Tablets Of Tolperisone, UK Journal Of Pharmaceutical And Biosciences, 2013; 1(1): 1-6

Alok Kumar Gupta, Anuj Mittal And Prof. K. K. Jha, Fast dissolving tablet- A Review. The pharma innovation, 2012; 1(1)

Yalla Karunakar Reddy, G. S.Valluri. Formulation and invitro evaluation of metronidazole tablets for colon targetted drug delivery system. Indo american journal of pharmaceutical sciences, 2016; 3 (12): 1534-1545.

Mohammad Saleem, Mohammad Shahin et al. Evaluation of tablets by friability apparatus. International journal of research in pharmacy and chemistry, 2014; 4(4): 837-840

Downloads

Published

2019-09-11

Issue

Vol. 6 No. 2 (2019)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.