Transethosomes: Rising Technology for Enhancing Transdermal Delivery of Drugs

Abstract

The skin has a total surface area of around 1.8 m² and serves as the human body's interface with the outside world. The transdermal method of medication delivery has sparked a lot of interest in pharmaceutical research since it eliminates a lot of the issues that come with the oral route. Despite the fact that the skin, especially the stratum corneum, is a barrier to most medication absorption, it does offer a substantial (1.2 m²) and accessible surface area for drug diffusion. Several methods have recently been explored to improve bioactive delivery through transdermal distribution. Iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, magnetophoresis, microneedles, and vesicular systems are some of the most common examples (liposomes, niosomes, elastic liposomes such as ethosomes, transfersomes and transethosomes). Transethosomes, which include both lipophilic and hydrophilic areas and may accept medicinal molecules with a broad range of solubility, seem to be the most promising of the bunch. Transethosomes may bend and pass through a constriction 5 to 10 times smaller than their own diameter. Because of the great deformability, intact vesicles may be penetrated more easily. Analgesics, anesthetics, corticosteroids, sex hormones, anticancer medicines, insulin, and other medications may all be delivered transdermally using these vesicles.