Drug Delivery Systems and Innovations
DOI:
https://doi.org/10.37591/tdd.v2i1.272Abstract
The aim of this study was to develop a controlled release system targeting antibiotic distribution to the stomach. The hydrogels were synthesized by utilizing chitosan, poly(acrylic acid) and poly(vinyl pyrrolidone) polymers cross linked with glutaraldehyde and N,N′-methylene bisacrylamide. Interpenetrating polymeric network (IPN) hydrogels were compare by varying the concentration of crosslinking agent (glutaraldehyde). The amount of chitosan, poly(acrylic acid), poly(vinyl pyrrolidone) and N, N’-methylenebisacrylamide were kept constant in all formulations. The effect of glutaraldehyde concentration on the swelling and relinquish characteristics were evaluated. Modalities used to assess the most optimal hydrogel formulation included high liquid chromatography, FTIR analysis, differential scanning calorimetry, swelling studies, in vitro drug release study, mucoadhesive study and scanning electron microscopy. The result showed that IPN hydrogels were more preponderant in swelling, more mucoadhesive and relinquished more drugs at lower pH values. Thus, it is believed that the antibiotic concentration in the stomach might be sustained through this formulation. The advanced properties of IPNs like swelling capacity, stability, biocompatibility, nontoxicity and biodegradability have magnetized considerable attention in pharmaceutical field especially in distributing bioactive molecules to the target site. In the past few years sundry research reports on the IPN predicated distribution systems showed that these carriers have emerged as a novel carrier in controlled drug distribution. The present review encompasses IPNs, their types, method of synthesis, factors which affects the morphology of IPNs, extensively studied IPN predicated drug distribution systems, and some natural polymers widely utilized for IPNs.
Keywords: Controlled Release, Glutaraldehyde, IPN, Stomach Targeted
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